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  1. The K-RAS oncogene is widely mutated in human cancers. Activating mutations in K-RAS give rise to constitutive signalling through the MAPK/ERK and PI3K/AKT pathways promoting increased cell division, reduced apop...

    Authors: Adam Naguib, Catherine H Wilson, David J Adams and Mark J Arends
    Citation: Journal of Molecular Signaling 2011 6:2
  2. Recent advances in our understanding of cell signaling have revealed assemblies of signaling components often viewed in fluorescence microscopy as very large, irregular "punctae". These punctae are often dynam...

    Authors: Hsien-yu Wang and Craig C Malbon
    Citation: Journal of Molecular Signaling 2011 6:1
  3. Ligands of Peroxisome proliferator-activated receptor gamma (PPARγ) can inhibit growth and promote apoptosis in various cancer cells, and thus have the potential to be utilized as anticancer drugs. This potent...

    Authors: Prajna Mishra, Suresh K Paramasivam, Ramesh P Thylur, Ajay Rana and Basabi Rana
    Citation: Journal of Molecular Signaling 2010 5:20
  4. The Wnt non-canonical pathway (Wnt5a > Frizzled-2 > cyclic GMP phosphodiesterase/Ca2+-mobilization pathway regulates the activation of NF-AT) is mediated by three mammalian Dishevelleds (Dvl1, Dvl2, and Dvl3) and...

    Authors: Li Ma, Ying Wang, Craig C Malbon and Hsien-yu Wang
    Citation: Journal of Molecular Signaling 2010 5:19
  5. TLN-4601 is a structurally novel farnesylated dibenzodiazepinone discovered using Thallion's proprietary DECIPHER® technology, a genomics and bioinformatics platform that predicts the chemical structures of secon...

    Authors: Paul M Campbell, Nadia Boufaied, James J Fiordalisi, Adrienne D Cox, Pierre Falardeau, Channing J Der and Henriette Gourdeau
    Citation: Journal of Molecular Signaling 2010 5:18
  6. SH2B1β is a signaling adaptor protein that has been shown to promote neuronal differentiation in PC12 cells and is necessary for the survival of sympathetic neurons. However, the mechanism by which SH2B1β may ...

    Authors: Wan-Chen Lu, Chien-Jen Chen, Hui-Chien Hsu, Hsin-Ling Hsu and Linyi Chen
    Citation: Journal of Molecular Signaling 2010 5:17
  7. Previous studies have demonstrated that seven transmembrane receptors (7TM-Rs) can associate with various chaperones to control their maturation and export. It has been shown for a few years now that 7TM-Rs ca...

    Authors: Maha M Hammad and Denis J Dupré
    Citation: Journal of Molecular Signaling 2010 5:16
  8. Children with Acute Lymphoblastic Leukemia (ALL) diagnosed with resistant phenotypes and those who relapse have a dismal prognosis for cure. In search for novel treatment strategies, we identified the AMP acti...

    Authors: Gilles M Leclerc, Guy J Leclerc, Guilian Fu and Julio C Barredo
    Citation: Journal of Molecular Signaling 2010 5:15
  9. Much attention has been recently focused on the role of cancer stem cells (CSCs) in the initiation and progression of solid malignancies. Since CSCs are able to proliferate and self-renew extensively due to th...

    Authors: Su-Ni Tang, Chandan Singh, Dara Nall, Daniel Meeker, Sharmila Shankar and Rakesh K Srivastava
    Citation: Journal of Molecular Signaling 2010 5:14
  10. The enzyme 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase (EC 4.1.2.15) catalyzes the first committed step in the shikimate pathway of tryptophan synthesis, an important precursor for the producti...

    Authors: Shilpa Ramani, Nandadevi Patil and Chelliah Jayabaskaran
    Citation: Journal of Molecular Signaling 2010 5:13
  11. A variety of pathways target CDKI p21WAF1/CIP1 expression at transcriptional, post-transcriptional as well as translational levels. We previously found that cell growth suppressing retinoid CD437 enhanced express...

    Authors: Liyue Zhang, Anil Wali, Joseph A Fontana, Marcia I Dawson and Arun K Rishi
    Citation: Journal of Molecular Signaling 2010 5:12
  12. Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of several biological processes, including the stress resistance, me...

    Authors: Sanjit K Roy, Rakesh K Srivastava and Sharmila Shankar
    Citation: Journal of Molecular Signaling 2010 5:10
  13. The gastrointestinal peptide hormone gastrin is known to regulate various cellular processes including proliferation, migration and metastasis in gastrointestinal (GI) cells. The studies described here were un...

    Authors: Prajna Mishra, Subramanian Senthivinayagam, Ajay Rana and Basabi Rana
    Citation: Journal of Molecular Signaling 2010 5:9
  14. Breast cancers show a lack of response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), despite 30% of tumors expressing EGFR. The mechanism of this resistance is unknown; however,...

    Authors: Kelly L Mueller, Zeng-Quan Yang, Ramsi Haddad, Stephen P Ethier and Julie L Boerner
    Citation: Journal of Molecular Signaling 2010 5:8
  15. CARP-1/CCAR1, a perinuclear phospho-protein, regulates signaling by adriamycin, steroids, or growth factors. However, intracellular events that regulate CARP-1-dependent cell growth are not fully understood.

    Authors: Yan Jiang, Vineshkumar T Puliyappadamba, Liyue Zhang, Wenjuan Wu, Anil Wali, Michael B Yaffe, Joseph A Fontana and Arun K Rishi
    Citation: Journal of Molecular Signaling 2010 5:7
  16. Ovarian cancer is the leading cause of death among gynecological cancers. Cisplatin is one of the most effective anticancer drugs used in the treatment of ovarian cancer. Development of resistance to cisplatin...

    Authors: Eswar Shankar, Chandreyi Basu, Brett Adkins, Wolfram Siede and Alakananda Basu
    Citation: Journal of Molecular Signaling 2010 5:4
  17. The cAMP-dependent protein kinase A (PKA) plays a pivotal role in virtually all cells, there being a multitude of important target molecules that are substrates for PKA in cell signaling. The spatial-temporal ...

    Authors: Jiangchuan Tao, Hsien-yu Wang and Craig C Malbon
    Citation: Journal of Molecular Signaling 2010 5:3
  18. Activation of the mammalian Ras-Raf-MEK-ERK MAPK signaling cascade promotes cellular proliferation, and activating Ras mutations are implicated in cancer onset and maintenance. This pathway, a therapeutic targ...

    Authors: Vanessa González-Pérez, David J Reiner, Jamie K Alan, Cicely Mitchell, Lloyd J Edwards, Vladimir Khazak, Channing J Der and Adrienne D Cox
    Citation: Journal of Molecular Signaling 2010 5:2
  19. AMP-activated protein kinase (AMPK) is a fuel-sensing enzyme that is activated when cells experience energy deficiency and conversely suppressed in surfeit of energy supply. AMPK activation improves insulin se...

    Authors: Rong Tao, Jun Gong, Xixi Luo, Mengwei Zang, Wen Guo, Rong Wen and Zhijun Luo
    Citation: Journal of Molecular Signaling 2010 5:1
  20. The human prostacyclin receptor (hIP) undergoes agonist-induced phosphorylation, desensitisation and internalisation and may be recycled to the plasma membrane or targeted for degradation by, as yet, unknown m...

    Authors: Peter D Donnellan and B Therese Kinsella
    Citation: Journal of Molecular Signaling 2009 4:7
  21. Glucocorticoid hormones (GCs) induce apoptosis of leukemic T-cells by transcriptional regulation via the GC receptor, GR. In the human leukemic CEM cell culture model, RCAN1 has been identified as one of the gene...

    Authors: Yasuko Hirakawa, Laura J Nary and Rheem D Medh
    Citation: Journal of Molecular Signaling 2009 4:6
  22. Despite intensive effort, currently no effective anti-Ras therapies have successfully reached clinical application. Previous studies suggest that the histone deacetylatse (HDAC) inhibitor romidepsin, which is ...

    Authors: Ariella B Hanker, Kevin D Healy, Jean Nichols and Channing J Der
    Citation: Journal of Molecular Signaling 2009 4:5
  23. Matrix Metalloproteinase functions in the remodeling of the extracellular matrix that is integral for many normal and pathological processes such as morphogenesis, angiogenesis, tissue repair, and tumor invasi...

    Authors: Jun Sun and William G Stetler-Stevenson
    Citation: Journal of Molecular Signaling 2009 4:4
  24. Most of breast cancers are considered sporadic and modulation of the two major genes BRCA1 and BRCA2 expressions caused by tissue-specific somatic mutations lead to this pathology. The nutritional intake of phyto...

    Authors: Samir Satih, Hélène Savinel, Nadège Rabiau, Luc Fontana, Yves-Jean Bignon and Dominique J Bernard-Gallon
    Citation: Journal of Molecular Signaling 2009 4:3
  25. Estradiol (E2) mediates various intracellular signaling cascades from the plasma membrane via several estrogen receptors (ERs). The pituitary is an estrogen-responsive tissue, and we have previously reported that...

    Authors: Yow-Jiun Jeng, Mikhail Y Kochukov and Cheryl S Watson
    Citation: Journal of Molecular Signaling 2009 4:2
  26. While evidence suggested that the activity states of Protein kinase B (AKT/PKB) and endothelial nitric oxide synthase (eNOS) play an important role in the progression of the Growth Hormone (GH) signal cascade,...

    Authors: Cong-Jun Li, Theodore H Elsasser and Stanislaw Kahl
    Citation: Journal of Molecular Signaling 2009 4:1
  27. Sustained agonist-promoted ubiquitination of β-arrestin has been correlated with increased stability of the GPCR – β-arrestin complex. Moreover, abrogation of β-arrestin ubiquitination has been reported to inh...

    Authors: Valerie A Mosser, Kymry T Jones, Katie M Hoffman, Nael A McCarty and Darrell A Jackson
    Citation: Journal of Molecular Signaling 2008 3:20
  28. A-kinase Anchoring Protein AKAP5 and AKAP12 both dock to the β2-adrenergic receptor, the former constitutively, the latter dynamically in response to activation of the receptor with agonist.

    Authors: Jiangchuan Tao and Craig C Malbon
    Citation: Journal of Molecular Signaling 2008 3:19
  29. The antihyperglycemic drug metformin may have beneficial effects on the prevention and treatment of cancer. Metformin is known to activate AMP-activated protein kinase (AMPK). It has also been shown to inhibit...

    Authors: Yongxian Zhuang and WKeith Miskimins
    Citation: Journal of Molecular Signaling 2008 3:18
  30. 16 can activate phospholipase Cβ (PLCβ) directly like Gαq. It also couples to tetratricopeptide repeat 1 (TPR1) which is linked to Ras activation. It is unknown whether PLCβ and TPR1 interact with the same regi...

    Authors: May YM Yu, Maurice KC Ho, Andrew MF Liu and Yung H Wong
    Citation: Journal of Molecular Signaling 2008 3:17
  31. Gadd45 genes have been implicated in stress signaling in response to physiological or environmental stressors, which results in cell cycle arrest, DNA repair, cell survival and senescence, or apoptosis. Eviden...

    Authors: Dan A Liebermann and Barbara Hoffman
    Citation: Journal of Molecular Signaling 2008 3:15
  32. Vascular permeability factor/Vascular endothelial growth factor (VPF/VEGF), a multifunctional cytokine, is a potent inducer of vascular permeability, an important early step in angiogenesis. It is known that t...

    Authors: Resham Bhattacharya, Sutapa Sinha, Su-Ping Yang, Chittaranjan Patra, Shamit Dutta, Enfeng Wang and Debabrata Mukhopadhyay
    Citation: Journal of Molecular Signaling 2008 3:14
  33. Influenza A virus (IVA) exploits diverse cellular gene products to support its replication in the host. The significance of the regulatory (β) subunit of casein kinase 2 (CK2β) in various cellular mechanisms i...

    Authors: Henju Marjuki, Christoph Scholtissek, Hui-Ling Yen and Robert G Webster
    Citation: Journal of Molecular Signaling 2008 3:13
  34. A previous study from this laboratory showed that Gα12 members participate in the production of inflammatory cytokines. In spite of the identification of B cell homeostasis responses regulated by Gα13, the functi...

    Authors: Song Jin Lee, Woo Hyung Lee, Chang Ho Lee and Sang Geon Kim
    Citation: Journal of Molecular Signaling 2008 3:12
  35. Conserved Wnt ligands are critical for signalling during development; however, various factors modulate their activity. Among these factors are the Secreted Frizzled-Related Proteins (SFRP). We previously isol...

    Authors: Thecla Constantinou, Fabrizio Baumann, Markus D Lacher, Susanne Saurer, Robert Friis and Arun Dharmarajan
    Citation: Journal of Molecular Signaling 2008 3:10
  36. Suspension cultures of Catharanthus roseus were used to evaluate ultraviolet-B (UV-B) treatment as an abiotic elicitor of secondary metabolites. A dispersed cell suspension culture from C. roseus leaves in late e...

    Authors: Shilpa Ramani and Chelliah Jayabaskaran
    Citation: Journal of Molecular Signaling 2008 3:9
  37. Vascular endothelial growth factor receptor-2 (VEGFR-2, KDR), a receptor tyrosine kinase, regulates mitogenic, chemotactic, hyperpermeability, and survival signals in vascular endothelial cells in response to ...

    Authors: Resham Bhattacharya, Junhye Kwon, Enfeng Wang, Priyabrata Mukherjee and Debabrata Mukhopadhyay
    Citation: Journal of Molecular Signaling 2008 3:8
  38. We have recently shown that epigallocatechin-3-gallate (EGCG), a polyphenolic compound from green tea, inhibits angiogenesis. However, the molecular mechanisms by which EGCG inhibits angiogenesis have never be...

    Authors: Sharmila Shankar, Qinghe Chen and Rakesh K Srivastava
    Citation: Journal of Molecular Signaling 2008 3:7
  39. The cellular localization of the α1D-adrenergic receptor (α1D-AR) is controversial. Studies in heterologous cell systems have shown that this receptor is expressed in intracellular compartments. Other studies sho...

    Authors: Mary L García-Cazarín, Jennifer L Smith, Kyle A Olszewski, Dan F McCune, Linda A Simmerman, Robert W Hadley, Susan D Kraner and Michael T Piascik
    Citation: Journal of Molecular Signaling 2008 3:6
  40. CB1 cannabinoid receptors are G-protein coupled receptors for endocannabinoids including anandamide and 2-arachidonoylglycerol. Because these arachidonic acid metabolites possess a 20-carbon polyene chain as the ...

    Authors: Lea W Padgett, Allyn C Howlett and Joong-Youn Shim
    Citation: Journal of Molecular Signaling 2008 3:5
  41. Wiskott Aldrich Syndromeprotein (WASP) has a unique regulatory role in sealing ring formation and bone resorption in osteoclasts. Here, using the TAT-transduction method, we show the possible rol...

    Authors: Tao Ma, Venkatesababa Samanna and Meenakshi A Chellaiah
    Citation: Journal of Molecular Signaling 2008 3:4
  42. Cutaneous melanoma is often resistant to chemo- and radiotherapy. This resistance has recently been demonstrated to be due, at least in part, to high activating transcription factor 2 (ATF-2) activity in these...

    Authors: Ying Huang, Jennifer Minigh, Sarah Miles and Richard M Niles
    Citation: Journal of Molecular Signaling 2008 3:3
  43. We have previously shown that c-FLIPL is a more potent inhibitor than c-FLIPS of Fas ligand-induced apoptosis and that c-FLIPL physically binds to Daxx, an alternative Fas-signaling adaptor. Here we examined whet...

    Authors: Dong-Joon Kim, Chan Park, Bermseok Oh and Young-Youl Kim
    Citation: Journal of Molecular Signaling 2008 3:2
  44. FAK localization to focal adhesions is essential for its activation and function. Localization of FAK is mediated through the C-terminal focal adhesion targeting (FAT) domain. Recent structural analyses have r...

    Authors: Danielle M Scheswohl, Jessica R Harrell, Zenon Rajfur, Guanghua Gao, Sharon L Campbell and Michael D Schaller
    Citation: Journal of Molecular Signaling 2008 3:1