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  1. Content type: Research article

    Forkhead box O (FoxO) transcription factors and E3 ubiquitin ligases such as Muscle RING finger 1 (MuRF1) are believed to participate in the regulation of skeletal muscle mass. The function of FoxO transcripti...

    Authors: Ann-Kristin Fjällström, Kim Evertsson, Marlene Norrby and Sven Tågerud

    Citation: Journal of Molecular Signaling 2014 9:9

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  2. Content type: Research article

    Cervical cancer is a chronic inflammatory disease of multifactorial etiology usually presenting in sexually active women. Exposure of neoplastic cervical epithelial cells to seminal plasma (SP) has been shown ...

    Authors: Anthonio O Adefuye, Kurt J Sales and Arieh A Katz

    Citation: Journal of Molecular Signaling 2014 9:8

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  3. Content type: Research article

    Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the GNA12 and GNA13 genes, respectively) in oncogenic pathways have uncovered a link between G12...

    Authors: Crystal Y Chia, Udhaya Kumari and Patrick J Casey

    Citation: Journal of Molecular Signaling 2014 9:6

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  4. Content type: Research article

    p38 mitogen-activated protein kinase has been implicated in both skeletal muscle atrophy and hypertrophy. T317 phosphorylation of the p38 substrate mitogen-activated protein kinase-activated protein kinase 2 (...

    Authors: Kim Evertsson, Ann-Kristin Fjällström, Marlene Norrby and Sven Tågerud

    Citation: Journal of Molecular Signaling 2014 9:2

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  5. Content type: Review

    Desensitization is a physiological feedback mechanism that blocks detrimental effects of persistent stimulation. G protein-coupled receptor kinase 2 (GRK2) was originally identified as the kinase that mediates...

    Authors: Kenji Watari, Michio Nakaya and Hitoshi Kurose

    Citation: Journal of Molecular Signaling 2014 9:1

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  6. Content type: Review

    Cancer remains a major health issue in the world and the effectiveness of current therapies is limited resulting in disease recurrence and resistance to therapy. Therefore to overcome disease recurrence and ha...

    Authors: Janani Panneerselvam, Anupama Munshi and Rajagopal Ramesh

    Citation: Journal of Molecular Signaling 2013 8:15

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  7. Content type: Review

    The heterogeneity and multigenetic nature of nervous system aging make modeling of it a formidable task in mammalian species. The powerful genetics, simple anatomy and short life span of the nematode Caenorhabdit...

    Authors: Chun-Hao Chen, Yen-Chih Chen, Hao-Ching Jiang, Chung-Kuan Chen and Chun-Liang Pan

    Citation: Journal of Molecular Signaling 2013 8:14

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  8. Content type: Review

    The importance of the neurotransmitter dopamine (DA) in the nervous system is underscored by its role in a wide variety of physiological and neural functions in both vertebrates and invertebrates. Binding of d...

    Authors: Pratima Pandey, Mahlet D Mersha and Harbinder S Dhillon

    Citation: Journal of Molecular Signaling 2013 8:13

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  9. Content type: Research article

    Insulin receptors are widely distributed in the brain, where they play roles in synaptic function, memory formation, and neuroprotection. Autophosphorylation of the receptor in response to insulin stimulation ...

    Authors: Nadezhda A Persiyantseva, Tatiana P Storozhevykh, Yana E Senilova, Lubov R Gorbacheva, Vsevolod G Pinelis and Igor A Pomytkin

    Citation: Journal of Molecular Signaling 2013 8:11

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  10. Content type: Research article

    The dependence of malignant properties of colorectal cancer (CRC) cells on IGF1R signaling has been demonstrated and several IGF1R antagonists are currently in clinical trials. Recently, we identified a novel ...

    Authors: Erik D Hedrick, Ekta Agarwal, Premila D Leiphrakpam, Katie L Haferbier, Michael G Brattain and Sanjib Chowdhury

    Citation: Journal of Molecular Signaling 2013 8:10

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  11. Content type: Research article

    Protrusions of cancer cells conferrers a vital function for cell migration and metastasis. Protein and RNA localization mechanisms have been extensively examined and shown to play pivotal roles for the functio...

    Authors: Kristine Raaby Jakobsen, Emilie Sørensen, Karin Kathrine Brøndum, Tina Fuglsang Daugaard, Rune Thomsen and Anders Lade Nielsen

    Citation: Journal of Molecular Signaling 2013 8:9

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  12. Content type: Research article

    Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in inva...

    Authors: Anna Fekete, Gábor Bőgel, Szabolcs Pesti, Zalán Péterfi, Miklós Geiszt and László Buday

    Citation: Journal of Molecular Signaling 2013 8:8

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  13. Content type: Review

    The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic regions of receptors ...

    Authors: Ping Xie

    Citation: Journal of Molecular Signaling 2013 8:7

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  14. Content type: Research article

    Ovarian cancer G protein coupled receptor 1 (OGR1) mediates inhibitory effects on cell migration in human prostate and ovarian cancer cells. However, the mechanisms and signaling pathways that mediate these in...

    Authors: Jing Li, Bin Guo, Jing Wang, Xiaoyan Cheng, Yan Xu and Jianli Sang

    Citation: Journal of Molecular Signaling 2013 8:6

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  15. Content type: Research article

    The phosphoinositide 3-kinase (PI3K)/Akt pathway is involved in neuroblastoma development where Akt/PKB activation is associated with poor prognosis. PI3K activity subsequently activates Akt/PKB, and as mutati...

    Authors: Susanne Fransson, Per Kogner, Tommy Martinsson and Katarina Ejeskär

    Citation: Journal of Molecular Signaling 2013 8:4

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  16. Content type: Research article

    Heterotrimeric guanine nucleotide binding proteins of the G12/13 subfamily, which includes the α-subunits Gα12 and Gα13, stimulate the monomeric G protein RhoA through interaction with a distinct subset of Rho-sp...

    Authors: Benjamin J Ritchie, William C Smolski, Ellyn R Montgomery, Elizabeth S Fisher, Tina Y Choi, Calla M Olson, Lori A Foster and Thomas E Meigs

    Citation: Journal of Molecular Signaling 2013 8:3

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  17. Content type: Research article

    Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that selectively activates and induces apoptosis in cancer cells, but not in normal cells. The cancer specific pro-apoptotic function of Par-...

    Authors: Faisal Thayyullathil, Siraj Pallichankandy, Anees Rahman, Jaleel Kizhakkayil, Shahanas Chathoth, Mahendra Patel and Sehamuddin Galadari

    Citation: Journal of Molecular Signaling 2013 8:2

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  18. Content type: Research article

    Autophagy is a cytoprotective, lysosomal degradation system regulated upon induced phosphatidylinositol 3-phosphate (PtdIns(3)P) generation by phosphatidylinositol 3-kinase class III (PtdIns3KC3) downstream of...

    Authors: Anja Gaugel, Daniela Bakula, Anneliese Hoffmann and Tassula Proikas-Cezanne

    Citation: Journal of Molecular Signaling 2012 7:16

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  19. Content type: Research article

    Evidence exists that oxidative stress promotes the tyrosine phosphorylation of N-methyl-D-aspartate receptor (NMDAR) subunits during post-ischemic reperfusion of brain tissue. Increased tyrosine phosphorylation o...

    Authors: Phillip H Beske and Darrell A Jackson

    Citation: Journal of Molecular Signaling 2012 7:15

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