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  1. Content type: Research article

    Forkhead box O (FoxO) transcription factors and E3 ubiquitin ligases such as Muscle RING finger 1 (MuRF1) are believed to participate in the regulation of skeletal muscle mass. The function of FoxO transcripti...

    Authors: Ann-Kristin Fjällström, Kim Evertsson, Marlene Norrby and Sven Tågerud

    Citation: Journal of Molecular Signaling 2014 9:9

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  2. Content type: Research article

    Cervical cancer is a chronic inflammatory disease of multifactorial etiology usually presenting in sexually active women. Exposure of neoplastic cervical epithelial cells to seminal plasma (SP) has been shown ...

    Authors: Anthonio O Adefuye, Kurt J Sales and Arieh A Katz

    Citation: Journal of Molecular Signaling 2014 9:8

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  3. Content type: Research article

    Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the GNA12 and GNA13 genes, respectively) in oncogenic pathways have uncovered a link between G12...

    Authors: Crystal Y Chia, Udhaya Kumari and Patrick J Casey

    Citation: Journal of Molecular Signaling 2014 9:6

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  4. Content type: Research article

    p38 mitogen-activated protein kinase has been implicated in both skeletal muscle atrophy and hypertrophy. T317 phosphorylation of the p38 substrate mitogen-activated protein kinase-activated protein kinase 2 (...

    Authors: Kim Evertsson, Ann-Kristin Fjällström, Marlene Norrby and Sven Tågerud

    Citation: Journal of Molecular Signaling 2014 9:2

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  5. Content type: Review

    Desensitization is a physiological feedback mechanism that blocks detrimental effects of persistent stimulation. G protein-coupled receptor kinase 2 (GRK2) was originally identified as the kinase that mediates...

    Authors: Kenji Watari, Michio Nakaya and Hitoshi Kurose

    Citation: Journal of Molecular Signaling 2014 9:1

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  6. Content type: Review

    Cancer remains a major health issue in the world and the effectiveness of current therapies is limited resulting in disease recurrence and resistance to therapy. Therefore to overcome disease recurrence and ha...

    Authors: Janani Panneerselvam, Anupama Munshi and Rajagopal Ramesh

    Citation: Journal of Molecular Signaling 2013 8:15

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  7. Content type: Review

    The heterogeneity and multigenetic nature of nervous system aging make modeling of it a formidable task in mammalian species. The powerful genetics, simple anatomy and short life span of the nematode Caenorhabdit...

    Authors: Chun-Hao Chen, Yen-Chih Chen, Hao-Ching Jiang, Chung-Kuan Chen and Chun-Liang Pan

    Citation: Journal of Molecular Signaling 2013 8:14

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  8. Content type: Review

    The importance of the neurotransmitter dopamine (DA) in the nervous system is underscored by its role in a wide variety of physiological and neural functions in both vertebrates and invertebrates. Binding of d...

    Authors: Pratima Pandey, Mahlet D Mersha and Harbinder S Dhillon

    Citation: Journal of Molecular Signaling 2013 8:13

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  9. Content type: Research article

    Insulin receptors are widely distributed in the brain, where they play roles in synaptic function, memory formation, and neuroprotection. Autophosphorylation of the receptor in response to insulin stimulation ...

    Authors: Nadezhda A Persiyantseva, Tatiana P Storozhevykh, Yana E Senilova, Lubov R Gorbacheva, Vsevolod G Pinelis and Igor A Pomytkin

    Citation: Journal of Molecular Signaling 2013 8:11

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  10. Content type: Research article

    The dependence of malignant properties of colorectal cancer (CRC) cells on IGF1R signaling has been demonstrated and several IGF1R antagonists are currently in clinical trials. Recently, we identified a novel ...

    Authors: Erik D Hedrick, Ekta Agarwal, Premila D Leiphrakpam, Katie L Haferbier, Michael G Brattain and Sanjib Chowdhury

    Citation: Journal of Molecular Signaling 2013 8:10

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  11. Content type: Research article

    Protrusions of cancer cells conferrers a vital function for cell migration and metastasis. Protein and RNA localization mechanisms have been extensively examined and shown to play pivotal roles for the functio...

    Authors: Kristine Raaby Jakobsen, Emilie Sørensen, Karin Kathrine Brøndum, Tina Fuglsang Daugaard, Rune Thomsen and Anders Lade Nielsen

    Citation: Journal of Molecular Signaling 2013 8:9

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  12. Content type: Research article

    Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in inva...

    Authors: Anna Fekete, Gábor Bőgel, Szabolcs Pesti, Zalán Péterfi, Miklós Geiszt and László Buday

    Citation: Journal of Molecular Signaling 2013 8:8

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  13. Content type: Review

    The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic regions of receptors ...

    Authors: Ping Xie

    Citation: Journal of Molecular Signaling 2013 8:7

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  14. Content type: Research article

    Ovarian cancer G protein coupled receptor 1 (OGR1) mediates inhibitory effects on cell migration in human prostate and ovarian cancer cells. However, the mechanisms and signaling pathways that mediate these in...

    Authors: Jing Li, Bin Guo, Jing Wang, Xiaoyan Cheng, Yan Xu and Jianli Sang

    Citation: Journal of Molecular Signaling 2013 8:6

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  15. Content type: Research article

    The phosphoinositide 3-kinase (PI3K)/Akt pathway is involved in neuroblastoma development where Akt/PKB activation is associated with poor prognosis. PI3K activity subsequently activates Akt/PKB, and as mutati...

    Authors: Susanne Fransson, Per Kogner, Tommy Martinsson and Katarina Ejeskär

    Citation: Journal of Molecular Signaling 2013 8:4

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  16. Content type: Research article

    Heterotrimeric guanine nucleotide binding proteins of the G12/13 subfamily, which includes the α-subunits Gα12 and Gα13, stimulate the monomeric G protein RhoA through interaction with a distinct subset of Rho-sp...

    Authors: Benjamin J Ritchie, William C Smolski, Ellyn R Montgomery, Elizabeth S Fisher, Tina Y Choi, Calla M Olson, Lori A Foster and Thomas E Meigs

    Citation: Journal of Molecular Signaling 2013 8:3

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  17. Content type: Research article

    Prostate apoptosis response-4 (Par-4) is a tumor-suppressor protein that selectively activates and induces apoptosis in cancer cells, but not in normal cells. The cancer specific pro-apoptotic function of Par-...

    Authors: Faisal Thayyullathil, Siraj Pallichankandy, Anees Rahman, Jaleel Kizhakkayil, Shahanas Chathoth, Mahendra Patel and Sehamuddin Galadari

    Citation: Journal of Molecular Signaling 2013 8:2

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  18. Content type: Research article

    Autophagy is a cytoprotective, lysosomal degradation system regulated upon induced phosphatidylinositol 3-phosphate (PtdIns(3)P) generation by phosphatidylinositol 3-kinase class III (PtdIns3KC3) downstream of...

    Authors: Anja Gaugel, Daniela Bakula, Anneliese Hoffmann and Tassula Proikas-Cezanne

    Citation: Journal of Molecular Signaling 2012 7:16

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  19. Content type: Research article

    Evidence exists that oxidative stress promotes the tyrosine phosphorylation of N-methyl-D-aspartate receptor (NMDAR) subunits during post-ischemic reperfusion of brain tissue. Increased tyrosine phosphorylation o...

    Authors: Phillip H Beske and Darrell A Jackson

    Citation: Journal of Molecular Signaling 2012 7:15

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  20. Content type: Research article

    Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify and charact...

    Authors: V Medina Villaamil, G Aparicio Gallego, M Valladares-Ayerbes, I Santamarina Caínzos and L. Miguel Antón Aparicio

    Citation: Journal of Molecular Signaling 2012 7:14

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  21. Content type: Review

    BH3 mimetics such as ABT-737 and navitoclax bind to the BCL-2 family of proteins and induce apoptosis through the intrinsic apoptosis pathway. There is considerable variability in the sensitivity of different ...

    Authors: Vasileios A Stamelos, Charles W Redman and Alan Richardson

    Citation: Journal of Molecular Signaling 2012 7:12

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  22. Content type: Review

    Colorectal cancer is the fourth most common form of cancer worldwide and ranks third among the cancer-related deaths in the US and other Western countries. It occurs with equal frequency in men and women, cons...

    Authors: Sanchita Roy and Adhip PN Majumdar

    Citation: Journal of Molecular Signaling 2012 7:11

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  23. Content type: Short report

    Neurons are known to employ the endogenous cannabinoid system to communicate with other cells of the CNS. Endocannabioid signaling recruits microglia toward neurons by engaging cannabinoid CB2 and abnormal cannab...

    Authors: Douglas McHugh, James Wager-Miller, Jeremy Page and Heather B Bradshaw

    Citation: Journal of Molecular Signaling 2012 7:10

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  24. Content type: Research article

    Dishevelled-3 (Dvl3) is a multivalent scaffold essential to cell signaling in development. Dsh/Dvls enable a myriad of protein-protein interactions in Wnt signaling. In the canonical Wnt/β-catenin pathway spec...

    Authors: Noriko Yokoyama, Nelli G Markova, Hsien-yu Wang and Craig C Malbon

    Citation: Journal of Molecular Signaling 2012 7:8

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  25. Content type: Research article

    The present study examines the hypothesis that Akt (protein kinase B)/mTOR (mammalian target of rapamycin) signaling is increased in hypertrophic and decreased in atrophic denervated muscle. Protein expression...

    Authors: Marlene Norrby, Kim Evertsson, Ann-Kristin Fjällström, Anna Svensson and Sven Tågerud

    Citation: Journal of Molecular Signaling 2012 7:7

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  26. Content type: Research article

    Somatostatin (SST) via five Gi coupled receptors namely SSTR1-5 is known to inhibit cell proliferation by cytostatic and cytotoxic mechanisms. Heterodimerization plays a crucial role in modulating the signal tran...

    Authors: Sajad A War and Ujendra Kumar

    Citation: Journal of Molecular Signaling 2012 7:5

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  27. Content type: Short report

    The canonical Wnt signaling pathway is crucial for embryonic development and adult tissue homeostasis. Activating mutations in the Wnt pathway are frequently associated with the pathogenesis of various types o...

    Authors: Victoria Fischer, Dex-Ann Brown-Grant and Feng-Qian Li

    Citation: Journal of Molecular Signaling 2012 7:6

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  28. Content type: Review

    Paget's disease of bone (PDB) is a skeletal disorder characterized by focal and disorganized increases in bone turnover and overactive osteoclasts. The discovery of mutations in the SQSTM1/p62 gene in numerous pa...

    Authors: Stephen McManus and Sophie Roux

    Citation: Journal of Molecular Signaling 2012 7:1

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  29. Content type: Research article

    Wnt/β-catenin signaling is involved in various aspects of skeletal muscle development and regeneration. In addition, Wnt3a and β-catenin are required for muscle-specific gene transcription in embryonic carcino...

    Authors: Shingo Tanaka, Kumiko Terada and Tsutomu Nohno

    Citation: Journal of Molecular Signaling 2011 6:12

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  30. Content type: Research article

    Synthetic GCs serve as therapeutic agents for some lymphoid leukemias because of their ability to induce transcriptional changes via the GC receptor (GR) and trigger apoptosis. Upregulation of the BH3-only mem...

    Authors: Jessica A Beach, Laura J Nary, Yasuko Hirakawa, Eli Holland, Rebeka Hovanessian and Rheem D Medh

    Citation: Journal of Molecular Signaling 2011 6:13

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  31. Content type: Short report

    Blood platelets undergo a carefully regulated change in shape to serve as the primary mediators of hemostasis and thrombosis. These processes manifest through platelet spreading and aggregation and are depende...

    Authors: Joseph E Aslan, Alex M Spencer, Cassandra P Loren, Jiaqing Pang, Heidi C Welch, Daniel L Greenberg and Owen JT McCarty

    Citation: Journal of Molecular Signaling 2011 6:11

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  32. Content type: Research article

    Post-transcriptional processing of pre-mRNA takes place in several steps and requires involvement of a number of RNA-binding proteins. How pre-mRNA processing is regulated is in large enigmatic. The catalytic ...

    Authors: Anne Kristin Aksaas, Anja CV Larsen, Marie Rogne, Ken Rosendal, Anne-Katrine Kvissel and Bjørn Steen Skålhegg

    Citation: Journal of Molecular Signaling 2011 6:10

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  33. Content type: Research article

    In the present study, we describe heterodimerization between human-Somatostatin Receptor 5 (hSSTR5) and β2-Adrenergic Receptor (β2AR) and its impact on the receptor trafficking, coupling to adenylyl cyclase and s...

    Authors: Rishi K Somvanshi, Nicole Chaudhari, Xiaofan Qiu and Ujendra Kumar

    Citation: Journal of Molecular Signaling 2011 6:9

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  34. Content type: Research article

    The family of A-kinase-anchoring proteins, AKAPs, constitutes a group of molecular scaffolds that act to catalyze dynamic interactions of protein kinase A, protein kinase C, tyrosine kinases, G-protein-coupled...

    Authors: Shujuan Gao, Hsien-yu Wang and Craig C Malbon

    Citation: Journal of Molecular Signaling 2011 6:8

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  35. Content type: Research article

    Metastatic colorectal cancer remains a serious health concern with poor patient survival. Although 5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) is the standard therapy for colorectal cancer, it has ...

    Authors: Jyoti Nautiyal, Shailender S Kanwar, Yingjie Yu and Adhip PN Majumdar

    Citation: Journal of Molecular Signaling 2011 6:7

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  36. Content type: Research article

    Aberrant Wnt/β-catenin signaling is associated with breast cancer even though genetic mutations in Wnt signaling components are rare. We have previously demonstrated that Rad6B, an ubiquitin conjugating enzyme...

    Authors: Brigitte Gerard, Larry Tait, Pratima Nangia-Makker and Malathy PV Shekhar

    Citation: Journal of Molecular Signaling 2011 6:6

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  37. Content type: Research article

    Following antigen recognition, naive T helper (Th; CD4+) cells can differentiate toward one of several effector lineages such as Th1 and Th2; each expressing distinctive transcriptional profiles of cytokine genes...

    Authors: Eyal Jacob, Reut Hod-Dvorai, Or Lea Ben-Mordechai, Yulia Boyko and Orly Avni

    Citation: Journal of Molecular Signaling 2011 6:5

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  38. Content type: Research article

    Classical mammalian mitogen-activated protein kinase (MAPK) pathways consist of a cascade of three successive phosphorylation events resulting in the phosphorylation of a variety of substrates, including anoth...

    Authors: Alexey Shiryaev, Gianina Dumitriu and Ugo Moens

    Citation: Journal of Molecular Signaling 2011 6:4

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  39. Content type: Research article

    A-kinase-anchoring proteins, AKAPs, constitute a family of scaffolds that play an essential role in catalyzing the spatial-temporal, dynamic interactions of protein kinase A, protein kinase C, tyrosine kinases...

    Authors: Shujuan Gao, Hsien-yu Wang and Craig C Malbon

    Citation: Journal of Molecular Signaling 2011 6:3

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