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  1. Heterotrimeric G proteins are ubiquitous signaling partners of seven transmembrane-domain G-protein-coupled receptors (GPCRs), the largest (and most important pharmacologically) receptor family in mammals. A n...

    Authors: Alexandra V Andreeva, Mikhail A Kutuzov and Tatyana A Voyno-Yasenetskaya
    Citation: Journal of Molecular Signaling 2007 2:13
  2. Wnt3a regulates a canonical signaling pathway in early development that controls the nuclear accumulation of β-catenin and its activation of Lef/Tcf-sensitive transcription of developmentally important genes.

    Authors: Noriko Yokoyama, Dezhong Yin and Craig C Malbon
    Citation: Journal of Molecular Signaling 2007 2:11
  3. We have recently shown that curcumin (a diferuloylmethane) inhibits growth and induces apoptosis, and also demonstrated that TRAIL induces apoptosis by binding to specific cell surface death receptors in prost...

    Authors: Sharmila Shankar, Qinghe Chen, Krishna Sarva, Imtiaz Siddiqui and Rakesh K Srivastava
    Citation: Journal of Molecular Signaling 2007 2:10
  4. We have previously derived highly similar lineage-restricted stem cell lines, RoSH and E-RoSH cell lines from mouse embryos and CD9hi SSEA-1- differentiated mouse embryonic stem cells, respectively. These cell li...

    Authors: Jianwen Que, Qizhou Lian, Reida M El Oakley, Bing Lim and Sai-Kiang Lim
    Citation: Journal of Molecular Signaling 2007 2:9
  5. We have previously shown that prostate cancer LNCaP cells are resistant to TRAIL, and downregulation of PI-3K/Akt pathway by molecular and pharmacological means sensitizes cells to undergo apoptosis by TRAIL a...

    Authors: Sharmila Shankar, Qinghe Chen, Imtiaz Siddiqui, Krishna Sarva and Rakesh K Srivastava
    Citation: Journal of Molecular Signaling 2007 2:7
  6. Clusterin (CLU) is an enigmatic molecule associated with various physiological processes and disease states. Different modes of cellular stress lead to increased CLU levels, and additionally numerous growth fa...

    Authors: Troels Schepeler, Francisco Mansilla, Lise L Christensen, Torben F Ørntoft and Claus L Andersen
    Citation: Journal of Molecular Signaling 2007 2:6
  7. PNRC transcriptionally regulates a wide range of RNA polymerase (pol) II-transcribed genes by functioning as a nuclear receptor coactivator. To search for additional PNRC-interacting proteins other than nuclea...

    Authors: Dujin Zhou, Shuping Zhong, Jing-Jing Ye, Keith M Quach, Deborah L Johnson and Shiuan Chen
    Citation: Journal of Molecular Signaling 2007 2:5
  8. The repulsive guidance molecule (RGM) proteins, originally discovered for their roles in neuronal development, have been recently identified as co-receptors in the bone morphogenetic protein (BMP) signaling pa...

    Authors: Peter J Halbrooks, Ru Ding, John M Wozney and Gerard Bain
    Citation: Journal of Molecular Signaling 2007 2:4
  9. Heterotrimeric G proteins are important for numerous signaling events in eukaryotes, serving primarily to transduce signals that are initiated by G protein-coupled receptors. It has recently become clear that ...

    Authors: Ian S Hagemann, Kirk D Narzinski and Thomas J Baranski
    Citation: Journal of Molecular Signaling 2007 2:3
  10. We have identified human ArhGAP9 as a novel MAP kinase docking protein that interacts with Erk2 and p38α through complementarily charged residues in the WW domain of ArhGAP9 and the CD domains of Erk2 and p38α...

    Authors: Boon K Ang, Chun Y Lim, Sharon S Koh, Neelamegam Sivakumar, Shahrizan Taib, Kim B Lim, Sohail Ahmed, Guna Rajagopal and Siew H Ong
    Citation: Journal of Molecular Signaling 2007 2:1
  11. The strict spatio-temporal control of Rho GTPases is critical for many cellular functions, including cell motility, contractility, and growth. In this regard, the prototypical Rho family GTPases, Rho, Rac, and...

    Authors: Hans Rosenfeldt, Maria Domenica Castellone, Paul A Randazzo and JSilvio Gutkind
    Citation: Journal of Molecular Signaling 2006 1:8
  12. Muscarinic acetylcholine receptors (mAChRs) undergo agonist-promoted internalization, but evidence suggesting that the mechanism of internalization is β-arrestin dependent has been contradictory and unclear. P...

    Authors: Kymry T Jones, Maria Echeverry, Valerie A Mosser, Alicia Gates and Darrell A Jackson
    Citation: Journal of Molecular Signaling 2006 1:7
  13. Seven members of the Mix family of paired-type homeoproteins regulate mesoderm/endoderm differentiation in amphibians. In mammals, the MIXL1 (Mix. 1 homeobox [Xenopus laevis]-like gene 1) gene is the sole represe...

    Authors: Wei Guo and Lalitha Nagarajan
    Citation: Journal of Molecular Signaling 2006 1:6
  14. The effects of estrogens on dopamine (DA) transport may have important implications for the increased incidence of neurological disorders in women during life stages when hormonal fluctuations are prevalent, e...

    Authors: Cheryl S Watson, Rebecca A Alyea, Bridget E Hawkins, Mary L Thomas, Kathryn A Cunningham and Adrian A Jakubas
    Citation: Journal of Molecular Signaling 2006 1:5
  15. Spatio-temporal control of extracellular signal-regulated kinase (ERK) activity, a critical determinant of the cell's response to growth factors, requires timely dephosphorylation of its regulatory tyrosine an...

    Authors: Yvet E Noordman, Patrick AM Jansen and Wiljan JAJ Hendriks
    Citation: Journal of Molecular Signaling 2006 1:4
  16. Taxol binds to the cellular microtubules and suppresses their dynamic instability. Development of tumor cell resistance to taxol is typically associated with increased expression of the drug efflux pump P-glyc...

    Authors: Hemant K Parekh, Mahesha Adikari and Bharathi Vennapusa
    Citation: Journal of Molecular Signaling 2006 1:3
  17. Mammalian receptors that couple to effectors via heterotrimeric G proteins (e.g., beta 2-adrenergic receptors) and receptors with intrinsic tyrosine kinase activity (e.g., insulin and IGF-I receptors) constitute ...

    Authors: Dezhong Yin, Elena Shumay, Hsien-yu Wang and Craig C Malbon
    Citation: Journal of Molecular Signaling 2006 1:2