Table 1 Expression of PAKs in human normal and cancerous tissues

Group I

PAK 1

Brain, muscle, spleen [6]

Bladder [55], breast [50, 51], colon [52], liver [56], lung [54], kidney [85]; ovarian [53, 86]

PAK 2

Ubiquitously expressed in most tissues

Liver [74], ovarian [86]

PAK 3

Brain [87]

Group II

PAK 4

Ubiquitously expressed in most tissues, predominantly in prostate, testis and colon [19, 22]

Colon [22], liver [76], pancreas [88]

PAK 5

Brain [20]

Colon [89], liver [77]

PAK 6

Brain, testis, prostate, kidney [21, 45]

Prostate [90], liver [78]