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Table 7 Genetic variations of TRAFs in human diseases

From: TRAF molecules in cell signaling and in human diseases

Diseases Genetic variations of TRAFs References
B cell malignancies
Multiple myeloma Deletions or inactivating mutations of TRAF3, TRAF2 [294296]
  SNPs of TRAF3 [297]
Splenic marginal zone lymphoma Deletions or inactivating mutations of TRAF3 [298, 299]
B cell chronic lymphocytic leukemia Deletions or inactivating mutations of TRAF3 [298]
Mantle cell lymphoma Deletions or inactivating mutations of TRAF3 [298]
Waldenström’s macroglobulinemia Deletions or inactivating mutations of TRAF3 [300]
Hodgkin lymphoma Deletion of TRAF3 [301]
Diffuse large B-cell lymphoma Inactivating mutations of TRAF2, TRAF5 [302]
Non-Hodgkin lymphoma SNPs of TRAF1 [303]
Carcinomas
Breast cancers Amplification of TRAF4 [304]
Lung cancers Amplification of TRAF4, TRAF6 [304, 305]
Osteosarcoma Amplification of TRAF6 [306]
Autoimmune diseases
Systemic lupus erythematosus SNPs of TRAF6, TRAF1/C5 [22, 307, 308]
Rheumatoid arthritis SNPs of TRAF5, TRAF6, TRAF1/C5 [22, 309311]
Immunodeficiencies
HSV-1 encephalitis Inactivating mutation of TRAF3 [312]
Other
Hypohidrotic ectodermal dysplasia Inactivating mutation of TRAF6 [313]