Table 3 E3 ligases that catalyze the ubiquitination of TRAFs
From: TRAF molecules in cell signaling and in human diseases
E3 ligases | Target TRAFs (Lys of ubiquitination) | Receptor signaling | References |
|---|---|---|---|
K-63 linked polyubiquitination | |||
Act1 | TRAF6 (Lys124) | IL-17R | [201] |
| Â | TRAF5 | IL-17R | [204] |
cIAP1/2 | TRAF3 and TRAF6 | RIG-I | [144] |
Pellino3 | TRAF6 (Lys124) | TLR3 | [202] |
K-48 linked polyubiquitination | |||
cIAP1/2 | TRAF2 | TNF-R2 | |
| Â | TRAF2 | M-CSFR | [207] |
| Â | TRAF2 and TRAF3 (Lys107 and Lys156) | CD40 and TLR4 | |
| Â | TRAF3 and TRAF6 | RIG-I | [144] |
Triad3A | TRAF3 | RIG-I | [203] |
AWP1 | TRAF2 | TNF-R1/2 | [208] |
SOCS2 | TRAF6 | AhR | [209] |
Siva-1 | TRAF2 | TCR | [210] |
Numbl | TRAF6 and TRAF5 | IL-1R | |
CHIP | TRAF2 | Cancer cell invasion | [213] |