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Table 2 Substrates of the E3 ligase activity of TRAFs

From: TRAF molecules in cell signaling and in human diseases

Substrates (Lys residues of ubiquitination) E3 ligases Receptor signaling References
TRAFs    
TRAF2 TRAF2 TNF-R1/2 [184]
TRAF3 TRAF3 TLR3, TLR4 [92, 185]
TRAF5 TRAF5 RIG-I [139]
TRAF6 TRAF6 TLRs, IL-1R [17, 23, 82, 89, 179, 186]
Receptors    
IL-17R TRAF6 IL-17 [156]
p75 (Lys274, 280 and 283) TRAF6 NGF [65]
TβRI TRAF6 TGFβ [169]
Kinases    
TAK1 (Lys158) TRAF6, TRAF2 TNF-R1/2 and IL-1R [187]
RIP1 (Lys377) TRAF2 TNF-R1 and IL-1R [179, 180]
TBK1 TRAF3 TLR3, TLR4 [17, 23, 81]
IKKε TRAF3 TLR3, TLR4 [17, 23, 81]
IRAK1 (Lys134 and 180) TRAF6 TLR7, TLR9, IL-1R [179, 188, 189]
Akt (Lys8 and 14) TRAF6 IL-1R, IGF-1R [190]
Fyn (K63) TRAF6 TLR4 [191]
Adaptor proteins    
NEMO (Lys285, 321, 325, 326 and 399) TRAF6 TLRs, IL-1R, NOD2 [17, 23, 82, 111, 192]
TRIF TRAF2, TRAF6 TLR3, TLR4 [98]
NESCA TRAF6 TrkA and p75 [193]
LAT (Lys88) TRAF6 TCR [176]
Other E3 ligases    
cIAP1/2 TRAF2 CD40 [37]
  TRAF6 TLR4-, IL-1R-induced autophagy [92]
Smurf2 TRAF2 TNF-R2 [194]
Transcription factors    
IRF7 (Lys444, 446, and 452) TRAF6 TLR7, TLR8, TLR9, LMP1, RIG-I [94, 142, 195]
IRF5 (Lys410 and 411) TRAF6 NOD2, TLR7, TLR9 [196, 197]
Regulators of mRNA stability    
Tristetraprolin TRAF2 TNF-R1 [198]
Autophagy proteins    
Beclin 1 (Lys117) TRAF6 TLR4-, IL-1R-induced autophagy [199]
NDP52 TRAF6 TLR3-induced autophagy [200]
Regulators of ROS production    
ECSIT TRAF6 TLR1, 2, 4-induced ROS production [93]