Figure 2

Binding specificity of BH3 only proteins. The activators (denoted with an “A”), BIM and PUMA bind to all the apoptosis inhibitors (denoted with an “I”). However, tBID and the sensitizers (denoted with a “S”) bind to a subset of the apoptosis inhibitors. There are some discrepancies in the literature (e.g., whether BMF binds MCL-1) and it is important to note that this diagram summarizes interactions (adapted from [7–9] in a binary fashion (interaction or no interaction) whereas in reality the interactions are better described by a range of binding affinities.