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Table 3 Dose Reduction Index (DRI) analysis for dasatinb in chemo-resistant HCT-116 colon cancer cells

From: Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells

Drug Reduction Index for Dasatinib
Fa DRI
CR HCT-116 (p53 wt)
0.25 13.37
0.50 18.19
0.75 24.76
  1. DRI represents the order of magnitude (fold) of dose reduction obtained for specific Fa in combination settings as compared to each drug alone.