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Table 2 Synergy analysis for dasatinib and curcumin combination therapy in chemo-resistant colon cancer cells

From: Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells

COMBINATION THERAPY COMBINATION INDEX (CI)
Dasatinib (μM) Curcumin (μM) CR HCT-116 (p53 wt) CR HT-29 (p53 mutant)
0.25 2.5 0.42 0.16
0.5 5.0 0.43 0.28
1.0 10.0 0.61 0.46
2.0 20.0 0.72 0.76
4.0 40.0 0.95 0.89
  1. Combination indices < 1.0 are increasingly supra-additive, whereas values > 1.0 are increasingly less than additive.