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Figure 7 | Journal of Molecular Signaling

Figure 7

From: Glycogen Synthase Kinase-3beta regulates Snail and beta-catenin during gastrin-induced migration of gastric cancer cells

Figure 7

Model representing the signaling pathway of G17-induced migration. Stimulation of G17/CCK2R pathway leads to activation of two separate signaling axes: (i) an activation of MLK3/JNK1 axis, which via activation of its downstream transcription factor c-Jun induces MMP7 transcription leading to increased migration; (ii) an induction of GSK3βSer9 phosphorylation (inhibition of axis) via a PI3Kinase-independent (and yet unknown) mechanism. This leads to an increase in Snail protein expression and β-catenin nuclear translocation, combination of which lead to increased MMP7 transcription and cell migration.

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Journal of Molecular Signaling

ISSN: 1750-2187