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Figure 8 | Journal of Molecular Signaling

Figure 8

From: Peroxisome proliferator-activated receptor gamma ligand-mediated apoptosis of hepatocellular carcinoma cells depends upon modulation of PI3Kinase pathway independent of Akt

Figure 8

Effect of PI3K and Akt inhibition on TRG-induced apoptosis resistance in Hep3B cells. (A) Subconfluent Hep3B cells were treated with 25 μM TRG in the presence (+) or absence (-) of serum for the indicated periods of time. Western Blot analyses were performed with the antibodies indicated. (B) Western analysis of Hep3B extracts treated with TRG in serum-containing media for 24 hours following a 1 hour pretreatment with none (lane 2), LY294002 (lane 3), LY303511 (lane 4), or Akt inhibitor VIII (lane 5).

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Journal of Molecular Signaling

ISSN: 1750-2187