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Figure 1 | Journal of Molecular Signaling

Figure 1

From: Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*

Figure 1

KDR, c-Src and SHP-1 co-precipitate and are part of one complex. (A) Serum starved HUVEC was treated with or without VEGF 10 ng/ml for 5 min and immunoprecipitated with antibody against KDR and immunoblotted with SHP-1 antibody. The first lane represents negative control (rabbit IgG). (B) Serum starved HUVEC was treated with or without VEGF 10 ng/ml for 5 min and immunoprecipitated with antibody against c-Src and immunoblotted with KDR and Src antibody.

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Journal of Molecular Signaling

ISSN: 1750-2187