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Figure 1 | Journal of Molecular Signaling

Figure 1

From: Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor

Figure 1

Interactive effects of AKT inhibitor and MEK1/2 inhibitor on EGCG-induced apoptosis. Human umbilical vein endothelial cells (HUVECs) were pretreated with AKT inhibitor-IV (1 μM) or MEK1/2 inhibitor PD98059 (10 μM) for 4 h, followed by treatment with EGCG (40 μM) for 2 h. Cells were harvested and TUNEL assay was performed as per manufacturer's instructions (Promega). Data represent mean ± SD. * = significantly different from control, P < 0.05.

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Journal of Molecular Signaling

ISSN: 1750-2187