Figure 2

Various conformations of arachidonyl derivatives in complex with proteins as found within the crystal structures of enzymes and binding proteins. The National Library of Medicine Protein Structure Data Base was searched for structures of arachidonic acid and its metabolites and analogs determined from X-ray crystal structures of known enzymes and binding proteins. (A) Arachidonic acid in complex with adipocyte lipid binding protein (1ADL), cyclooxygenase active site of COX-2 (ICVU), prostaglandin H2 synthase-1 (1DIY), and human serum albumin (1GNJ); (B) Methyl arachidonyl fluorophosphonate in complex with fatty acid amide hydrolase (1MT5); (C) 5,8,11,14,17-Eicosapentaenoic acid in complex with peroxisome proliferator activated receptor delta (3GWX) and prostaglandin endoperoxide H synthase-1 (1IGX).