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Figure 6 | Journal of Molecular Signaling

Figure 6

From: G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential signaling to MAPK and GPCR recycling

Figure 6

Schematic of GPCR-associated AKAP79 and AKAP250: regulation of downstream signaling by beta 2 -adrenergic receptors. The AKAPs provide multivalent docking sites for PKA, PKC, and PP2B as well as other protein kinases, phosphoprotein phosphatases, and adaptor molecules (not shown). Binding of the beta-adrenergic agonist leads to activation of the receptor (β2AR*, #1) and activation of Gs > adenylylcyclase activation > cyclic AMP accumulation > PKA activation (#2). The association of AKAP250 with the receptor is markedly enhanced by PKA phosphorylation of the receptor and scaffold, whereas AKAP79 association with the receptor is constitutive. AKAP79 mediates downstream signal switching from Gs to Gi-mediated activation of the mitogen-activated protein kinase cascade leading to Erk1,2 (#3). AKAP250 mediates the resensitization and recycling of the desensitized and internalized receptor (#4). Through docking of critical enzymes, the AKAP provide high spatial resolution and localization of downstream signaling. See the text for more details.

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Journal of Molecular Signaling

ISSN: 1750-2187