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Figure 3 | Journal of Molecular Signaling

Figure 3

From: CK2beta gene silencing increases cell susceptibility to influenza A virus infection resulting in accelerated virus entry and higher viral protein content

Figure 3

siRNA-mediated silencing of CK2β increases virus titers. (a) A549 cells were transfected with either control (white bars) or CK2β (black bars) siRNA for 48 h, then infected at an MOI of 5, 0.1, or 0.001 and incubated for 24 h. Virus in cell supernatants was titrated in MDCK cells. (b) A549 cells were inoculated with virus (MOI = 5) and were either left untreated (white bars) or treated with the CK2 inhibitor DMAT or the activator spermine (black bars). Virus in cell supernatants was titrated at 24 h p.i.. Mean virus titers ± SE from 3 independent experiments are given as a percentage of the control mean and as PFU/ml. * P < 0.05 and **P < 0.005 between the indicated groups.

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Journal of Molecular Signaling

ISSN: 1750-2187