Data-driven modeling of cellular stimulation, signaling and output response in RAW 264.7 cells

Table 4 Prediction results of PLS regression using all vital signaling metrics

	G-CSF	IL-1α	IL-6	IL-10	MIP-1α	RANTES	TNFα
number of vital metrics	74	70	49	85	97	76	78
R ²	0.90	0.49	0.72	0.66	0.54	0.69	0.76

For each cytokine, a PLS regression model using from 49 to 97 most informative (vital) signaling metrics was as predictive as the complete model that used all 231 metrics.