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Figure 8 | Journal of Molecular Signaling

Figure 8

From: Seminal plasma induces the expression of IL-1α in normal and neoplastic cervical cells via EP2/EGFR/PI3K/AKT pathway

Figure 8

Schematic summary highlighting the role of SP and its constituents (PGE 2 and EGF) in the regulation of signaling pathway mediating IL-1α (IL-1 alpha) expression in cervical epithelial cells. Expressed IL-1α can then bind to its cognate receptor, interleukin-1 receptor type I (IL-1RI) to recruit interleukin-1 receptor accessory protein (IL-1RAP) on same cell leading to the activation of IL-1α signaling pathway (IL-1a pathway).

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