Figure 1
From: The role of p21-activated kinases in hepatocellular carcinoma metastasis
Domain structure of PAKs. A conserved N-terminal p21/GTPase domain (PBD) and a C-terminal serine/threonine kinase domain are shared by all family members of PAK. An autoinhibition mechanism is found available in all PAKs. Binding of activated Cdc42 or Rac1 to the PBD releases group I PAKs from the auto-inhibitory (AID) domain and activates the kinases. AID is also present in PAK5, whereas an autoinhibitory psuedosubstrate has been indentified in PAK4 and PAK6.