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Figure 3 | Journal of Molecular Signaling

Figure 3

From: Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and −8, and matrix metalloproteinase-2

Figure 3

Expression of dominant active Gα12 in MDA-MB-231 cells induces secretion of cytokines IL-6 andIL-8, and MMP-2. (A) Protein array analysis of factors present in conditioned media. MDA-MB-231 cells were transfected either with control vector (Mock) or Gα12QL as indicated. Following a 72 h incubation period, media was harvested and subject to antibody-based arrays; see Methods for details. (B) Enlarged areas of the indicated regions of the arrays shown in (A). Quantification of data from three arrays is shown in (C). Bars represent the mean ± S.E. of quadruplicate determinations; IL-6 (p = 0.007), IL-8 (p = 0.003), MMP-2 (p = 0.007).

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Journal of Molecular Signaling

ISSN: 1750-2187