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Figure 2 | Journal of Molecular Signaling

Figure 2

From: Breast cancer cell invasion mediated by Gα12 signaling involves expression of interleukins-6 and −8, and matrix metalloproteinase-2

Figure 2

Factors secreted from MCF10A cells expressing dominant active Gα12 stimulate the invasion of MDA-MB-231 cells. (A) Experimental scheme illustrating experimental conditions. MCF10A cells were transfected as described under “Methods”. Following a 48 h incubation period, the conditioned media was collected and placed on MDA-MB-231 cells in 6 well plates. After 12 h, the MDA-MB-231 cells were harvested and subjected to an invasion assay. The results are shown in (B). Data are presented as a mean of triplicate determinations from a single experiment that is representative of two independent experiments. Bars represent the mean ± S.E. *p < 0.05.

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Journal of Molecular Signaling

ISSN: 1750-2187