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Table 4 Deubiquitinating enzymes that target TRAFs

From: TRAF molecules in cell signaling and in human diseases

DUBs TRAFs Receptor signaling References
Ubiquitin-specific proteases
CYLD TRAF2, TRAF6 CD40, XEDAR, EDAR, RANK [222, 223]
  TRAF2, TRAF6 IL-1β, TNFα [224]
USP2a TRAF2 TNFR1 [225]
  TRAF6 IL-1β, RIG-I [226]
USP4 TRAF2, TRAF6 TNFα [227]
  TRAF6 TLR4, IL-1R [228]
USP20 TRAF6 IL-1β [229]
USP25 TRAF5, TRAF6 IL-17R [204]
Ovarian tumor (OTU) family of DUBs
DUBA (OTUD5) TRAF3 IL-1β, TLR9 [216]
  TRAF3 TLR3, TLR4, TLR7, RIG-I, MDA-5 [185]
OTUB1 TRAF3, TRAF6 RIG-I [230]
OTUB2 TRAF3, TRAF6 RIG-I [230]
A20 TRAF6 TLR4, TLR2 [231, 232]
Novel cellular DUBs    
MCPIP1 TRAF2, TRAF3, TRAF6 IL-1, TLR4 [219]