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Table 4 Deubiquitinating enzymes that target TRAFs

From: TRAF molecules in cell signaling and in human diseases

DUBs

TRAFs

Receptor signaling

References

Ubiquitin-specific proteases

CYLD

TRAF2, TRAF6

CD40, XEDAR, EDAR, RANK

[222, 223]

 

TRAF2, TRAF6

IL-1β, TNFα

[224]

USP2a

TRAF2

TNFR1

[225]

 

TRAF6

IL-1β, RIG-I

[226]

USP4

TRAF2, TRAF6

TNFα

[227]

 

TRAF6

TLR4, IL-1R

[228]

USP20

TRAF6

IL-1β

[229]

USP25

TRAF5, TRAF6

IL-17R

[204]

Ovarian tumor (OTU) family of DUBs

DUBA (OTUD5)

TRAF3

IL-1β, TLR9

[216]

 

TRAF3

TLR3, TLR4, TLR7, RIG-I, MDA-5

[185]

OTUB1

TRAF3, TRAF6

RIG-I

[230]

OTUB2

TRAF3, TRAF6

RIG-I

[230]

A20

TRAF6

TLR4, TLR2

[231, 232]

Novel cellular DUBs

   

MCPIP1

TRAF2, TRAF3, TRAF6

IL-1, TLR4

[219]