From: TRAF molecules in cell signaling and in human diseases
DUBs | TRAFs | Receptor signaling | References |
---|---|---|---|
Ubiquitin-specific proteases | |||
CYLD | TRAF2, TRAF6 | CD40, XEDAR, EDAR, RANK | |
 | TRAF2, TRAF6 | IL-1β, TNFα | [224] |
USP2a | TRAF2 | TNFR1 | [225] |
 | TRAF6 | IL-1β, RIG-I | [226] |
USP4 | TRAF2, TRAF6 | TNFα | [227] |
 | TRAF6 | TLR4, IL-1R | [228] |
USP20 | TRAF6 | IL-1β | [229] |
USP25 | TRAF5, TRAF6 | IL-17R | [204] |
Ovarian tumor (OTU) family of DUBs | |||
DUBA (OTUD5) | TRAF3 | IL-1β, TLR9 | [216] |
 | TRAF3 | TLR3, TLR4, TLR7, RIG-I, MDA-5 | [185] |
OTUB1 | TRAF3, TRAF6 | RIG-I | [230] |
OTUB2 | TRAF3, TRAF6 | RIG-I | [230] |
A20 | TRAF6 | TLR4, TLR2 | |
Novel cellular DUBs | Â | Â | Â |
MCPIP1 | TRAF2, TRAF3, TRAF6 | IL-1, TLR4 | [219] |