Skip to main content

Table 1 TRAFs directly and indirectly employed by the TNF-R superfamily

From: TRAF molecules in cell signaling and in human diseases

Receptors TRAFs References
Receptors containing TRAF-interacting motifs
TNF-R2 TRAF2 [26, 34]
  TRAF1, 3 via TRAF2 [26]
CD40 TRAF2, 3, 5, 6 [27, 28, 35]
  TRAF1 via TRAF2 [28]
BAFF-R TRAF3, 6 [3638]
  TRAF2 via TRAF3 [28]
BCMA TRAF1, 2, 3, 5, 6 [39, 40]
TACI TRAF2, 3, 5, 6 [2, 28, 41]
LTβR TRAF2, 3, 5 [29, 4247]
CD27 TRAF2, 3, 5 [1, 48, 49]
CD30 TRAF1, 2, 3, 5 [1, 2]
4-1BB TRAF1, 2, 3 [1, 2]
OX40 TRAF1, 2, 3, 5, 6 [1, 2, 5052]
GITR TRAF1, 2, 3, 4, 5 [1, 2, 53, 54]
RANK TRAF1, 2, 3, 5, 6 [1, 2, 55, 56]
HVEM TRAF1, 2, 3, 5 [1, 2, 57]
Troy TRAF2, 5, 6 [58]
XEDAR TRAF3, 6 [59]
Fn14 TRAF2, 6 [33, 60]
Death receptors   
TNF-R1 TRAF2 via TRADD [6163]
  TRAF5 via RIP1 [64]
p75NTR TRAF1, 2, 3, 4, 5, 6 [2, 65, 66]
EDAR TRAF1, 3, 6 [63]
FAS TRAF2 via FADD [63]
DR3 TRAF2 via TRADD [63]
DR6 TRAF2 via TRADD [63]
TRAIL-R1 TRAF2 via RIP1 [67]