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Figure 6 | Journal of Molecular Signaling

Figure 6

From: TRAF molecules in cell signaling and in human diseases

Figure 6

TRAFs in signaling by IL-17R. Upon ligand binding, heteromeric IL-17RA and IL-17RC recruit TRAF6, TRAF2 and TRAF5 via Act1. TRAF6 mediates IL-17-induced activation of NF-κB1, IkBζ, C/EBPδ and C/EBPβ. TRAF2 and TRAF5 transduce the IL-17 signals to stabilize mRNA transcripts of chemokines and cytokines by recruiting SF2 and by inducing activation of MAPKs. In contrast, TRAF3 and TRAF4 inhibit IL-17 signaling. TRAF3 interacts with IL-17RA and IL-17RC and thus interferes with the recruitment of Act1 by IL-17Rs, while TRAF4 binds to Act1 and interrupts the recruitment of TRAF6 by Act1.

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