Skip to main content
Figure 5 | Journal of Molecular Signaling

Figure 5

From: TRAF molecules in cell signaling and in human diseases

Figure 5

TRAFs in signaling by RIG-I. Upon ligand binding, RIG-I recruits TRAF3, TRAF6, TRAF2 and TRAF5 to mitochondria via MAVS. TRAF3 mediates RIG-I-induced IRF3 but not NF-κB1 activation. TRAF6 mediates RIG-I-induced IRF7 activation and also contributes to activation of NF-κB1, JNK, and p38. TRAF2 is important for p38 activation, and both TRAF2 and TRAF5 also contribute to activation of IRF3 and NF-κB1 in RIG-I signaling.

Back to article page