From: NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significance
Types | Name | Function | Evidences (R/E/C/I)* | Refs. |
---|---|---|---|---|
Transporters | Betaine/γ-aminobutyric acid transporter (BGT1) | Uptake of betaine. | R, E | |
Sodium dependent myo-inositol transporter (SMIT) | Uptake of myo-inositiol. | R, E, I | ||
Taurine transporter (TAUT) | Uptake of taurine. | R, I | [29] | |
Urea transporter (UT-A) | Transport urea. | R, E, I | ||
Aquaporin 1 (AQP1) | Water channel. | R, C, I | [35] | |
Aquaporin 2 (AQP2) | R, C, I | |||
Aquaporin 4 (AQP4) | C, I | [58] | ||
Kinases | Sgk1 | Involved in dehydration natriuresis. | R, E, C, I | |
Chaperones | HSP70 | Heat shock protein | R, E, I | |
Enzymes | Aldose reductase (AR) | Converts glucose to sorbitol. | R, I | |
β1,3-Glucuronosyltransferase-I | Synthesis of Glycosaminoglycan | R, C, I | [48] | |
Aromatic l-amino acid decarboxylase (AAD) | Synthesis of dopamine. | R, E, I | [59] | |
Inducible nitric oxide synthase (iNOS) | Synthesis of nitric oxide. | R, C, I | [54] | |
Cytochrome | CYP2E1 | Metabolism of xenobiotics. | R, E, I | [42] |
CYP3A7 | R, E, I | [43] | ||
Cell adhesion molecules | CD24 | T cell proliferation and conversion to memory cells. | C, I | [45] |
Cytokines | TNF-α | Cytokines. | E, C, I | |
IL-6 | R, C, I | [54] | ||
Monocyte chemoattractant protein-1 (MCP-1) | Recruitment of monocytes and T cells to inflammatory region. | R, E, I | ||
Growth factors | VEGFC | Lymphangiogenesis | E, C | [40] |
Others | S100A4/metastasin-1 | Cell motility and tumor metastasis. | R, C, I |