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Table 1 Molecular targets of NFAT5

From: NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significance

Types Name Function Evidences (R/E/C/I)* Refs.
Transporters Betaine/γ-aminobutyric acid transporter (BGT1) Uptake of betaine. R, E [15, 18, 27]
Sodium dependent myo-inositol transporter (SMIT) Uptake of myo-inositiol. R, E, I [17, 28]
Taurine transporter (TAUT) Uptake of taurine. R, I [29]
Urea transporter (UT-A) Transport urea. R, E, I [34, 36]
Aquaporin 1 (AQP1) Water channel. R, C, I [35]
Aquaporin 2 (AQP2) R, C, I [36, 37, 57]
Aquaporin 4 (AQP4) C, I [58]
Kinases Sgk1 Involved in dehydration natriuresis. R, E, C, I [38, 51]
Chaperones HSP70 Heat shock protein R, E, I [28, 30]
Enzymes Aldose reductase (AR) Converts glucose to sorbitol. R, I [19, 26, 28]
β1,3-Glucuronosyltransferase-I Synthesis of Glycosaminoglycan R, C, I [48]
Aromatic l-amino acid decarboxylase (AAD) Synthesis of dopamine. R, E, I [59]
Inducible nitric oxide synthase (iNOS) Synthesis of nitric oxide. R, C, I [54]
Cytochrome CYP2E1 Metabolism of xenobiotics. R, E, I [42]
CYP3A7 R, E, I [43]
Cell adhesion molecules CD24 T cell proliferation and conversion to memory cells. C, I [45]
Cytokines TNF-α Cytokines. E, C, I [25, 46]
IL-6 R, C, I [54]
Monocyte chemoattractant protein-1 (MCP-1) Recruitment of monocytes and T cells to inflammatory region. R, E, I [49, 50]
Growth factors VEGFC Lymphangiogenesis E, C [40]
Others S100A4/metastasin-1 Cell motility and tumor metastasis. R, C, I [6062]
  1. *R – Reporter gene assay, E – EMSA, C – ChIP, I – Inhibition of NFAT5 (gene knockdown/gene knockout).