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Table 1 Molecular targets of NFAT5

From: NFAT5 in cellular adaptation to hypertonic stress – regulations and functional significance

Types

Name

Function

Evidences (R/E/C/I)*

Refs.

Transporters

Betaine/γ-aminobutyric acid transporter (BGT1)

Uptake of betaine.

R, E

[15, 18, 27]

Sodium dependent myo-inositol transporter (SMIT)

Uptake of myo-inositiol.

R, E, I

[17, 28]

Taurine transporter (TAUT)

Uptake of taurine.

R, I

[29]

Urea transporter (UT-A)

Transport urea.

R, E, I

[34, 36]

Aquaporin 1 (AQP1)

Water channel.

R, C, I

[35]

Aquaporin 2 (AQP2)

R, C, I

[36, 37, 57]

Aquaporin 4 (AQP4)

C, I

[58]

Kinases

Sgk1

Involved in dehydration natriuresis.

R, E, C, I

[38, 51]

Chaperones

HSP70

Heat shock protein

R, E, I

[28, 30]

Enzymes

Aldose reductase (AR)

Converts glucose to sorbitol.

R, I

[19, 26, 28]

β1,3-Glucuronosyltransferase-I

Synthesis of Glycosaminoglycan

R, C, I

[48]

Aromatic l-amino acid decarboxylase (AAD)

Synthesis of dopamine.

R, E, I

[59]

Inducible nitric oxide synthase (iNOS)

Synthesis of nitric oxide.

R, C, I

[54]

Cytochrome

CYP2E1

Metabolism of xenobiotics.

R, E, I

[42]

CYP3A7

R, E, I

[43]

Cell adhesion molecules

CD24

T cell proliferation and conversion to memory cells.

C, I

[45]

Cytokines

TNF-α

Cytokines.

E, C, I

[25, 46]

IL-6

R, C, I

[54]

Monocyte chemoattractant protein-1 (MCP-1)

Recruitment of monocytes and T cells to inflammatory region.

R, E, I

[49, 50]

Growth factors

VEGFC

Lymphangiogenesis

E, C

[40]

Others

S100A4/metastasin-1

Cell motility and tumor metastasis.

R, C, I

[6062]

  1. *R – Reporter gene assay, E – EMSA, C – ChIP, I – Inhibition of NFAT5 (gene knockdown/gene knockout).