Table 1 C. elegans genes that regulate neuronal aging
Genes | Identity | Major function |
|---|---|---|
Genes that promote neuronal integrity during aging | ||
daf-16 | FoxO transcription factor | Upregulation of stress resistance genes |
hsf-1 | Heat shock transcription factor | Upregulation of small heat shock protein expression |
mec-1 | EGF and Kunitz domain-containing ECM protein | Mechanosensory transduction, nerve attachment |
mec-2 | Stomatin-like | Mechanosensory transduction |
mec-4 | DEG/ENaC family sodium channel | Mechanosensory transduction |
mec-5 | Atypical collagen | Mechanosensory transduction, nerve attachment |
mec-6 | Paraoxonase | Mechanosensory transduction |
mec-9 | EGF and Kunitz domain-containing ECM protein | Mechanosensory transduction, nerve attachment |
mec-10 | DEG/ENaC family sodium channel | Mechanosensory transduction |
mec-12 | α-tubulin | Mechanosensory transduction, axon transport |
jkk-1 | JNK kinase | Activation of JNK; synaptic vesicle localization |
jnk-1 | c-Jun N-terminus kinase (JNK) | Heat and stress response; locomotion |
mek-1 | Mitogen activated protein kinase (MAPK) kinase/MKK7 | Stress and starvation response |
lmn-1 | Laminin | Regulation of nuclear organization and function |
ptl-1 | Tau/microtubules-associated protein | Microtubule stabilization? |
unc-13 | Munc-13 | Synaptic vesicle fusion |
unc-18 | Munc-18 | Synaptic vesicle docking |
Genes that accelerate neuronal aging | ||
daf-2 | Insulin-like growth factor receptor | Larval development, dauer formation, etc |
dgk-1 | Diacylglycerol kinase | Inhibition of synapse transmission |
slo-1 | BK-type potassium channel | Muscle inactivation, neuronal excitability, etc |