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Figure 2 | Journal of Molecular Signaling

Figure 2

From: Neuronal aging: learning from C. elegans

Figure 2

Temporal evolution of neuronal defects during aging in C. elegans . The same ALM neurons in the wild type were imaged at different time points over the animals’ lifespan; lateral view, anterior is up. Neurons were labeled by a touch cell-specific GFP reporter. Scale bar = 5 μm or 1 μm (A, insets). (A) The posterior process of the ALM neuron (arrow) remained static from D5 to D14 but retracted later. Arrowheads mark an ectopic sprouting from the soma, which was truncated between D3 and D5, and completely retracted on D15. Insets highlight the development of a bubble-like lesion in the proximal ALM process. The animal died on D16. (B) The ALM grew a posterior process on D1, which continued to lengthen between D1 and D5, and branched at D8 (arrow). An ectopic branch emerged from the dorsal side of the cell body at D12 (lower panel, double arrows). On D17, another short sprouting grew at the anterior aspect of the neuron (arrowhead). The three images of the right lower panel were taken from different focal planes. Images were originally published in the Proceedings of the National Academies of Sciences of the U.S.A. and reused with permission [30].

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