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Figure 1 | Journal of Molecular Signaling

Figure 1

From: Neuronal aging: learning from C. elegans

Figure 1

Age-dependent defects of C. elegans touch receptor neurons. (A) Schematic diagram of C. elegans touch receptor neurons, lateral view. For simplicity, only one of the bilateral ALM and PLM neurons was shown. VNC, ventral nerve cord. (B) Immunofluorescence of acetylated microtubules in the soma of young and old ALM neurons. Compared to the young neuron, the old ALM neuron showed aberrant sprouting from the soma (asterisks) and marked disorganization of microtubules. (C) Age-dependent axon defects in the touch neurons. ALM or PLM neurons were visualized in live animals with GFP expressed from the touch neuron-specific mec-4 promoter. Arrows mark bubble-like lesions (upper left, ALM), beading (upper right, PLM), blebbing (lower left, PLM) and wavy processes (lower right, PLM). Asterisks label neurite branching in the PLM.

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