Table 2 A summary of known effectors of C. elegans dopamine receptors and their physiological functions
Receptor | G-proteins | Effectors | Physiological role |
|---|---|---|---|
DOP-1 | EGL-30/ Gαq | ITR-1, PKC-1, EGL-8 | Tap habituation, locomotion, acetylcholine release [77, 78, 90, 91]. |
DOP-2 | GPA-14, GOA-1 | Unknown | Associative learning, anterior touch habituation, suppression of octopamine-mediated CREB activation [32, 78, 79, 88]. |
DOP-3 | GOA-1/ Gαo/i | DAG kinase (DGK-1) | Enhancement of 2-nonanone avoidance, negative regulation of locomotion, and octanol hyper-sensitization [90, 92, 96]. |
RGS protein (EAT-16) | |||
RGS-3 | |||
DOP-4 | Not known | Not known | General enhancement of avoidance responses [93]. |