Figure 5From: Differential PKA activation and AKAP association determines cell fate in cancer cells Differential PKA activation decides cell survival or apoptotic fate. FET cells treated with Growth Factors (or GF that includes a combination of Transferrin and Insulin) or OSI-906 (1 μM) activated PKA (A). FET cells treated with GF showed cAMP-dependent activation of PKA whereas FET cells treated with OSI-906 showed cAMP-independent activation of PKA as determined by cAMP assay (B). FET cells treated with GF showed an upregulation of XIAP, whereas cells treated with OSI-906 showed a downregulation of XIAP (C). All experiments were repeated three times independently with 3 replicas per repeat for the ANOVA analysis (* P < 0.001).Back to article page