Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Table 3 Somatic mutations in mapkapk-5 in cancer tissues

Primary tissue	Unique mutated samples	% mutated	Total unique samples	Mutation data	references
bilary tract	0	0%	2
breast	0	0%	201
CNS	0	0%	477
haematopoietic and lymphoid tissue	0	0%	27
kidney	0	0%	28
large intestine	0	0%	42
lung	2	1%	171	c.406 C > T: L136L	[49]
				c.450 G > A: K150K	[49]
				c.1371A > G: E457E	[49]
melanoma	1	4%	25	c.890 G > A: L297E	[54]
ovary	1	1%	85	c.660 + 2 T > A: intronic mutation	[50]
pancreas	0	0%	31
pleura	0	0%	1
prostate	0	0%	58
salivary gland	0	0%	9
skin	0	0%	6
stomach	0	0%	34
testis	0	0%	13
upper aerodigestive tract	0	0%	19
urinary tract	0	0%	2