Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

Table 1 Somatic mutations in mapk6/erk3 in cancer tissues

Primary tissue	Unique mutated samples	% mutated	Total unique samples	Mutation data	references
bilary tract	0	0%	2
breast	0	0%	201
CNS	0	0%	477
haematopoietic and lymphoid tissue	0	0%	27
kidney	0	0%	28
large intestine	0	0%	42
lung	3	1%	359	c.190 C > T : R64C	[48]
				c.700 G > T: G234C	[48]
				c.868 C > G: L290V	[48]
ovary	1	1%	85	c.1466A > C: K489T	[50]
pancreas	0	0%	31
pleura	0	0%	1
prostate	0	0%	58
salivary gland	0	0%	9
skin	2	25%	8	c.868 C > G: L290V	[51]
skin	2	25%	8	c.1522 G > A: E508K	[51]
stomach	0	0%	34
testis	0	0%	13
upper aerodigestive tract	0	0%	19
urinary tract	0	0%	2