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Figure 6 | Journal of Molecular Signaling

Figure 6

From: Assembly of Dishevelled 3-based supermolecular complexes via phosphorylation and Axin

Figure 6

CK1δ/ϵ regulates formation of Dvl3-based very large punctae. Treatment with CK1δ/ϵ inhibitor decreases number as well as apparent size of the punctae. F9 cells were co-transfected with Rfz1 and GFP- and HA-tagged wild-type Dvl3. Cells were stimulated with Wnt3a and images of live cells were captured at the times indicated. After 10 min post Wnt stimulation, a CK1δ/ϵ selective inhibitor (IC261, 5 μM) was added and cell images captured continuously. Results displayed are images captured at 5, 10, and 15 min post treatment with IC261. The images displayed are representative of two or more separate experiments.

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