Figure 7

The cytotoxic role for SSTR2/SSTR3. Stable cotransfectants of SSTR2 and SSTR3 were subjected to 24 h treatment with SST (1, 50 nM and 1 μM), L-779976 (10 and 100 nM) and L-796778 (25 and 50 nM) in the presence or absence of serum-starvation and processed for PARP-1 expression by Western blot analysis. Cells treated with SST and receptor-specific agonists displayed increased expression of PARP-1. Note a high basal PARP-1 expression in serum-deprived conditions with no significant changes in response to SST and receptor specific agonists. β-Tubulin was used as a loading control. Data represent mean ± S.D of three independent experiments.