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Figure 6 | Journal of Molecular Signaling

Figure 6

From: NADPH oxidase mediates the oxygen-glucose deprivation/reperfusion-induced increase in the tyrosine phosphorylation of the N-methyl-D-aspartate receptor NR2A subunit in retinoic acid differentiated SH-SY5Y Cells

Figure 6

Inhibition of NADPH oxidase activity decreases NMDAR-mediated cell death following exposure to OGD. Differentiated SH-SY5Y cells exhibit an increased susceptibility to cell death after 6 hours of NMDA (5 mM) stimulation following 40 minutes of OGD as assessed by the ethidium homodimer exclusion assay. This enhanced NMDAR-induced cell death is diminished with NADPH oxidase inhibition using DPI (100 nM). Data represent % mean cell death ± S.E.M from three independent experiments consisting of 10–12 determinants (askteriks * indicates a p <0.05 from normoxic control; ANOVA with post hoc Bonferroni test)

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Journal of Molecular Signaling

ISSN: 1750-2187