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Table 4 EGFR scores for the interactors obtained by STRING

From: Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway

Node 1 Node 2 Combined score

Node 1 Node 2 Combined score

UBC

PLCG1

0.845

SOS1

PTPN11

0.999

*STAT1

EGFR

0.998

SHC1

PTPN1

0.920

SOS1

GRB2

0.999

PTPN6

EGFR

0.998

GRB2

PLCG1

0.992

EGFR

*PLCG1

0.999

EPS15

EGF

0.983

SRC

ERBB2

0.855

EGF

STAT3

0.996

PTPN1

STAT3

0.966

ERRFI1

EGF

0.956

SRC

EGF

0.999

PTPN1

EGFR

0.999

STAT1

STAT3

0.996

BTC

ERBB2

0.990

ERBB2

EGF

0.999

UBC

EGF

0.922

GRB2

CBL

0.999

SRC

PLCG1

0.989

SHC1

STAT3

0.869

SRC

NCK1

0.931

NCK1

CBL

0.948

ERBB2

EREG

0.966

SOS1

CBL

0.972

GRB2

ERBB2

0.999

EPS15

GRB2

0.992

EPS15

EGFR

0.999

EGFR

*STAT3

0.999

SHC1

TGFA

0.724

SRC

GRB2

0.992

EGF

CBL

0.980

PTPN6

STAT1

0.781

SOS1

SRC

0.986

EGFR

EREG

0.999

GRB2

STAT3

0.973

SHC1

SRC

0.806

GRB2

EGF

0.998

*GRB2

EGFR

0.999

PTPN6

CBL

0.714

ERRFI1

ERBB2

0.933

SHC1

PLCG1

0.913

EPS15

UBC

0.995

PTPN1

SRC

0.999

CBL

PLCG1

0.999

SHC1

ERBB2

0.998

PTPN1

ERBB2

0.884

PTPN11

ERBB2

0.990

SHC1

PTPN6

0.766

EGFR

*EGF

0.999

SHC1

CBL

0.999

TGFA

ERBB2

0.992

PTPN11

CBL

0.960

EGFR

CBL

0.999

PTPN6

GRB2

0.969

NCK1

PLCG1

0.708

ERRFI1

EGFR

0.999

PTPN1

GRB2

0.999

PTPN6

EGF

0.976

PTPN11

GRB2

0.999

*SRC

EGFR

0.999

SHC1

EGF

0.996

SOS1

ERBB2

0.961

SRC

STAT3

0.999

STAT1

PTPN11

0.998

NCK1

EGF

0.979

SHC1

PTPN11

0.971

EGFR

ERBB2

0.999

STAT1

SRC

0.992

SRC

PTPN11

0.802

PTPN11

EGF

0.996

*SOS1

EGFR

0.999

EPS15

SRC

0.807

SOS1

PLCG1

0.943

SHC1

STAT1

0.830

PTPN6

STAT3

0.893

   

PTPN11

PLCG1

0.727

   

PTPN11

STAT3

0.988

   

UBC

EGFR

0.999

   

UBC

CBL

0.995

   

ERBB2

PLCG1

0.982

   

EGF

PLCG1

0.981

   

EPS15

CBL

0.960

   

ERBB2

STAT3

0.989

   

PTPN1

EGF

0.979

   

PTPN6

PTPN11

0.961

   

SHC1

EGFR

0.999

   

PTPN6

SRC

0.780

   

BTC

EGFR

0.999

   

*PTPN11

EGFR

0.999

   

SOS1

NCK1

0.998

   

STAT1

EGF

0.995

   

*NCK1

EGFR

0.998

   

*TGFA

EGFR

0.999

   

SOS1

EGF

0.971

   

SRC

CBL

0.998

   

SHC1

SOS1

0.999

   

SHC1

GRB2

0.999

   
  1. The table shows all associations in STRING provided with a probabilistic confidence score for EIP and between proteins belongs to this EGFR interactome network. Each node represents a protein which by edges may be interacting with any other. Each score represents a rough estimate of how likely a given association describes a functional linkage between two proteins that is at least as specific as that between an average pair of proteins annotated on the same ‘map’ or ‘pathway’ in KEGG. *Proteins showed by STRING and APID as EIP.