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Table 4 EGFR scores for the interactors obtained by STRING

From: Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway

Node 1 Node 2 Combined score Node 1 Node 2 Combined score
UBC PLCG1 0.845 SOS1 PTPN11 0.999
*STAT1 EGFR 0.998 SHC1 PTPN1 0.920
SOS1 GRB2 0.999 PTPN6 EGFR 0.998
GRB2 PLCG1 0.992 EGFR *PLCG1 0.999
EPS15 EGF 0.983 SRC ERBB2 0.855
EGF STAT3 0.996 PTPN1 STAT3 0.966
ERRFI1 EGF 0.956 SRC EGF 0.999
PTPN1 EGFR 0.999 STAT1 STAT3 0.996
BTC ERBB2 0.990 ERBB2 EGF 0.999
UBC EGF 0.922 GRB2 CBL 0.999
SRC PLCG1 0.989 SHC1 STAT3 0.869
SRC NCK1 0.931 NCK1 CBL 0.948
ERBB2 EREG 0.966 SOS1 CBL 0.972
GRB2 ERBB2 0.999 EPS15 GRB2 0.992
EPS15 EGFR 0.999 EGFR *STAT3 0.999
SHC1 TGFA 0.724 SRC GRB2 0.992
EGF CBL 0.980 PTPN6 STAT1 0.781
SOS1 SRC 0.986 EGFR EREG 0.999
GRB2 STAT3 0.973 SHC1 SRC 0.806
GRB2 EGF 0.998 *GRB2 EGFR 0.999
PTPN6 CBL 0.714 ERRFI1 ERBB2 0.933
SHC1 PLCG1 0.913 EPS15 UBC 0.995
PTPN1 SRC 0.999 CBL PLCG1 0.999
SHC1 ERBB2 0.998 PTPN1 ERBB2 0.884
PTPN11 ERBB2 0.990 SHC1 PTPN6 0.766
EGFR *EGF 0.999 SHC1 CBL 0.999
TGFA ERBB2 0.992 PTPN11 CBL 0.960
EGFR CBL 0.999 PTPN6 GRB2 0.969
NCK1 PLCG1 0.708 ERRFI1 EGFR 0.999
PTPN1 GRB2 0.999 PTPN6 EGF 0.976
PTPN11 GRB2 0.999 *SRC EGFR 0.999
SHC1 EGF 0.996 SOS1 ERBB2 0.961
SRC STAT3 0.999 STAT1 PTPN11 0.998
NCK1 EGF 0.979 SHC1 PTPN11 0.971
EGFR ERBB2 0.999 STAT1 SRC 0.992
SRC PTPN11 0.802 PTPN11 EGF 0.996
*SOS1 EGFR 0.999 EPS15 SRC 0.807
SOS1 PLCG1 0.943 SHC1 STAT1 0.830
PTPN6 STAT3 0.893    
PTPN11 PLCG1 0.727    
PTPN11 STAT3 0.988    
UBC EGFR 0.999    
UBC CBL 0.995    
ERBB2 PLCG1 0.982    
EGF PLCG1 0.981    
EPS15 CBL 0.960    
ERBB2 STAT3 0.989    
PTPN1 EGF 0.979    
PTPN6 PTPN11 0.961    
SHC1 EGFR 0.999    
PTPN6 SRC 0.780    
BTC EGFR 0.999    
*PTPN11 EGFR 0.999    
SOS1 NCK1 0.998    
STAT1 EGF 0.995    
*NCK1 EGFR 0.998    
*TGFA EGFR 0.999    
SOS1 EGF 0.971    
SRC CBL 0.998    
SHC1 SOS1 0.999    
SHC1 GRB2 0.999    
  1. The table shows all associations in STRING provided with a probabilistic confidence score for EIP and between proteins belongs to this EGFR interactome network. Each node represents a protein which by edges may be interacting with any other. Each score represents a rough estimate of how likely a given association describes a functional linkage between two proteins that is at least as specific as that between an average pair of proteins annotated on the same ‘map’ or ‘pathway’ in KEGG. *Proteins showed by STRING and APID as EIP.
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Journal of Molecular Signaling

ISSN: 1750-2187