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Table 3 EGFR interaction partners obtained by APID

From: Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway

PROTEIN INTERACTORS EXPERIMENTS PROVENANCE CLUSTER COEFFICIENT
EGFR_HUMAN/GRB2_HUMAN 18 BIND - HPRD - IntAct - MINT - BioGRID 0.018153
EGF_HUMAN/EGFR_HUMAN 15 BIND - DIP - HPRD - IntAct - MINT - BioGRID 0.242424
EGFR_HUMAN/SHC1_HUMAN 12 BIND - DIP - HPRD - IntAct - MINT - BioGRID 0.100999
PTN1_HUMAN/EGFR_HUMAN 9 HPRD - MINT - BioGRID 0.070715
EGFR_HUMAN/RASA1_HUMAN 7 BIND - HPRD - MINT - BioGRID 0.122177
CRK_HUMAN/EGFR_HUMAN 6 HPRD - MINT - BioGRID 0.049001
SRC_HUMAN/EGFR_HUMAN 5 HPRD - MINT - BioGRID 0.033376
PLCG1_HUMAN/EGFR_HUMAN 5 BIND - HPRD - MINT - BioGRID 0.064601
EGFR_HUMAN/STAT3_HUMAN 4 BIND - HPRD - IntAct - BioGRID 0.078719
EGFR_HUMAN/JAK2_HUMAN 4 HPRD - MINT - BioGRID 0.117345
NCK1_HUMAN/EGFR_HUMAN 4 HPRD - MINT - BioGRID 0.022317
GRB10_HUMAN/EGFR_HUMAN 4 HPRD - MINT - BioGRID 0.22792
TGFA_HUMAN/EGFR_HUMAN 3 BIND - DIP - HPRD - IntAct - BioGRID 0.044118
PTN11_HUMAN/EGFR_HUMAN 3 HPRD - MINT - BioGRID 0.09284
SH3K1_HUMAN/EGFR_HUMAN 3 HPRD - MINT - BioGRID 0.108213
P85A_HUMAN/EGFR_HUMAN 3 BIND - HPRD - MINT 0.047572
EGFR_HUMAN/STAT1_HUMAN 3 HPRD - BioGRID 0.080438
EGFR_HUMAN/VAV2_HUMAN 3 HPRD - BioGRID 0.235294
EGFR_HUMAN/STA5A_HUMAN 3 HPRD - BioGRID 0.193759
SOS1_HUMAN/EGFR_HUMAN 3 HPRD - BioGRID 0.155465
EGFR_HUMAN/PTN6_HUMAN 3 HPRD - BioGRID 0.101232
  1. The table shows 21 proteins with greater evidence for EIP (EGFR interacting proteins). The cluster coefficient, a graph parameter that indicates the degree of inter-connection of the group of proteins directly interact to a query protein, in our case, EGFR. A cluster coefficient value close to zero indicates that the protein pair is very close, a value away from zero shows that the protein pair is farthest.
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Journal of Molecular Signaling

ISSN: 1750-2187