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Table 1 BCL-2 family proteins

From: Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine

BH3 only pro-apoptotic proteins

Multi-domain pro-apoptotic

Anti-apoptotic proteins

Activators

  

BIM

BAK

BCL-2

BID

BAX

BCL-XL

PUMA

BOK

BCL-W

  

MCL-1

Sensitizers

 

BFL/BCL-2A1

NOXA

 

BCL-B

BAD

  

BMF

  

HRK

  

BIK

  

BNIP3

  
  1. Of the BH3 only proteins, BID, BIM and possibly PUMA are considered apoptosis activators and the others as apoptosis sensitizers. BOK is an apoptosis effector expressed primarily in the ovary.
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Journal of Molecular Signaling

ISSN: 1750-2187