Effects of dasatinib and/or curcumin on the growth of (A) CR HCT-116 and (B) CR HT-29 colon cancer cells: Growth as determined by MTT assay after 72-h incubation with incremental doses of dasatinib and/or curcumin. All CR cells were exposed to 50 μM 5-FU and 1.25 μM oxaliplatin with or without (control) dasatinib and/or curcumin. This treatment strategy was utilized in all subsequent experiments. Dose response curves were generated for the drugs using Calcusyn 2.0 (Biosoft). All assays were performed in quadreplicates. A fractional effect (Fa) of 1 represents complete toxicity for the drug(s), whereas Fa value of "0" indicates no effect.