Skip to main content
Figure 7 | Journal of Molecular Signaling

Figure 7

From: Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells

Figure 7

Effect of small-molecule inhibitors on C2C12 cell proliferation and differentiation. C2C12 cells were cultured without inhibitors (A-D) and with 1 μM FH535 (E-H), 1 μM GW9662 (I-L) and 3.6 nM K-252a (M-P), then immunostained with anti-troponin T (A, B, E, F, I, J, M, N) and anti-β-catenin (C, D, G, H, K, L, O, P) antibodies. FH535 interferes with β-catenin/Tcf complex formation, whereas GW9662 is structurally similar to FH535, but does not interfere with complex formation. K252a is a Trk kinase inhibitor, which phosphorylates β-catenin at tyrosine 654.

Back to article page

Journal of Molecular Signaling

ISSN: 1750-2187