Skip to main content
Figure 5 | Journal of Molecular Signaling

Figure 5

From: Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells

Figure 5

Wnt4 reduces Wnt-3a-induced transcriptional activity in myoblasts. Reporter assays were performed using TOP/FLASH and FOP/FLASH (luciferase assay) in C2C12 cells. Wnt3a significantly increases luciferase activity in TOP over FOP. (A) Wnt4 has no effect on luciferase activity, whereas Wnt4 inhibits Wnt3a activity. (B) Wnt5a poorly inhibits Wnt3a activity. Bars are the means of four independent experiments. *P < 0.01 between TOP and FOP; P < 0.01 between Wnt3a and Wnt3a + Wnt4 in TOP; P < 0.02 between Wnt3a and Wnt3a + Wnt5a in TOP.

Back to article page

Journal of Molecular Signaling

ISSN: 1750-2187