Figure 6

Effect of p53 knockdown on cisplatin sensitization by NSC109268. Cells were transfected with or without control non-targeting siRNA or p53 siRNA as described under Methods. Cells were then treated with or without 2 μM NSC102968 and 40 μM cisplatin. A, Western blot analysis was performed with total cell lysates as described under legend to Figure 4. B, Cells were stained with Yo-Pro-1 and PI as described under legend to Figure 5.