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Figure 3 | Journal of Molecular Signaling

Figure 3

From: Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-1 epithelial cells independently of Ras signaling inhibition

Figure 3

Romidepsin does not induce cleavage of caspase-3 or PARP. NIH 3T3 cells (A) and RIE-1 cells (B) stably infected with pBabe.puro vector or encoding H-Ras(G12V), K-Ras(G12V), or N-Ras(G12D) were treated with 5 nM romidepsin for 72 h or 1 μM staurosporine (STS) for 24 h. Cell lysates were analyzed by western blotting with antibodies to PARP, caspase-3, and β-actin (loading control). Data shown are representative of at least three independent experiments.

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Journal of Molecular Signaling

ISSN: 1750-2187