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Table 3 Top 10% and 20% most significant time-dependent signaling metrics as identified via PLS

From: Data-driven modeling of cellular stimulation, signaling and output response in RAW 264.7 cells

Cytokine Top 10% metrics Top 20% metrics (not including those in top 10%)
G-CSF JNK lg: AUC, maximum JNK lg: mean, @ 30 min, derivative @ 10 min, @ 10 min
  JNK sh: AUC JNK sh: derivative @ 10 min, maximum, mean, @ 30 min, @ 10 min
   P38: @ 30 min, @ 10 min
   ERK1: derivative @ 10 min
   ERK2: derivative @ 10 min
   RSK: derivative @ 10 min, @ 30 min
   NF-κB p65: @ 10 min, AUC, @ 30 min, maximum
   PKCM: derivative @ 30 min
IL-1α JNK lg: maximum JNK lg: AUC, @ 30 min, mean, derivative @ 10 min, @ 10 min
  JNK sh: AUC JNK sh: maximum, mean, derivative @ 10 min, @ 30 min, @ 10 min
   ERK1: derivative @ 10 min
   ERK2: derivative @ 10 min
   P38: @ 30 min
   RSK: derivative @ 10 min
   PKCM: derivative @ 30 min
   NF-κB p65: @ 10 min, AUC, maximum, @ 30 min
IL-6 STAT3: mean, AUC, derivative @ 3 min, @ 3 min, maximum, @ 1 min, derivative @ 1 min, @ 10 min STAT3: @ 30 min
   STAT1α: derivative @ 10 min
   STAT1β: derivative @ 10 min
IL-10 RSK: derivative @ 10 min  
  ERK2: derivative @ 10 min  
  ERK1: derivative @ 10 min  
  JNK sh: derivative @ 10 min, @ 30 min, AUC, @ 10 min JNKsh: maximum, mean
  JNK lg: @ 30 min, @ 10 min, derivative @ 10 min JNK lg: AUC, maximum, mean
  P38: derivative @ 10 min P38: @ 30 min
  NF-κB p65: AUC NF-κB p65: maximum, @ 30 min, @ 10 min, mean
   GSK3A: derivative @ 10 min
MIP-1α JNK lg: mean, maximum, AUC  
  NF-κB p65: @ 30 min, derivative @ 30 min NF-κB p65: @ 10 min
  JNK sh: maximum, AUC JNK sh: mean, derivative @ 10 min
  STAT5: 1 min, derivative @ 1 min  
   ERK2: derivative @ 10 min
   ERK1: derivative @ 10 min
   PKCM: maximum, derivative @ 30 min
   P38 @ 30 min, maximum, @ 10 min
   STAT1α: derivative @ 30 min
RANTES JNK lg: maximum, AUC, mean JNK lg: derivative @ 10 min, @ 30 min, @ 10 min
  JNK sh: maximum, AUC, derivative @ 10 min JNK sh: mean, @ 10 min, @ 30 min
  ERK2: derivative @ 10 min  
  ERK1: derivative @ 10 min  
   RSK: derivative @ 10 min
   PKCM: derivative @ 30 min, maximum
   P38: derivative @ 10 min, @ 30 min
   NF-κB p65: @ 10 min
TNFα NF-κB p65: @ 30 min, @ 10 min  
  JNK lg: mean, maximum, AUC  
   PKCM: derivative @ 30 min, @ 30 min, maximum
   P38: @ 30 min, @ 10 min, AUC
   JNK sh: maximum, AUC, mean
   RSK: @ 30 min
   ERK1: @ 30 min
   Rps6: derivative @ 30 min
   ERK2: @ 30 min