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Figure 4 | Journal of Molecular Signaling

Figure 4

From: Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential

Figure 4

Effects of resveratrol on the expressions of Bcl-2 family members and IAPs. (A and B), Effects of resveratrol on protein expression of Bcl-2 family members. Cells were treated with resveratrol (0–20 μM) for 24 or 48 h. The expressions of Noxa, Bim, Bak, Bax, Bid, PUMA, Bcl-2, and Bcl-XL were examined by Western blot analysis. Actin antibody was used as a loading control. BimEL = Bim extra large, BimL = Bim large, BimS = Bim short. (C), Effects of resveratrol on the expressions of IAPs. Cells were treated with resveratrol (0–20 μM) for 24 or 48 h. Crude proteins were subjected to SDS-PAGE and immunoblotted with antibody specific for XIAP, survivin, cIAP1 or cIAP2. β-actin antibody was used as a loading control.

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Journal of Molecular Signaling

ISSN: 1750-2187