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Table 1 Kinetic analysis of BMP2 and BMP12 binding interactions with the RGM coreceptors

From: Role of RGM coreceptors in bone morphogenetic protein signaling

BMP2

Kon(M-1s-1)

Koff(s-1)

KD(nM)

RGMa

1.48 × 105

3.64 × 10-4

2.46

RGMb

4.72 × 104

2.56 × 10-4

5.43

RGMc

8.61 × 104

3.63 × 10-4

4.22

BMP12

K on (M -1 s -1 )

K off (s -1 )

K D (nM)

RGMa

1.27 × 105

1.79 × 10-4

1.41

RGMb

5.69 × 104

1.18 × 10-4

2.06

RGMc

7.56 × 104

9.22 × 10-5

1.22

  1. BIAevaluation software was used to analyze the binding kinetics of BMP2 or BMP12 binding to each RGM co-receptor. In all cases, kinetic parameters were obtained from global analysis of protein binding kinetics [see Additional file 1 for binding curves]
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Journal of Molecular Signaling

ISSN: 1750-2187