Domain structure of E2F8. E2F8 includes two E2F homology domains, both of which contain the RRXYD consensus motif that interacts directly with DNA. The region 400–630 has 16% amino acid identity with GAP-43, a known activator of heterotrimeric G proteins. Approximate boundaries of the homology regions are indicated. The percentage of amino acid identity to human E2F1 and E2F7 is indicated for the regions 1–200 and 610–867.