Figure 5
From: Molecular mechanisms mediating the G protein-coupled receptor regulation of cell cycle progression
Src family kinase-dependent cell cycle control. Gq-, G12/13- and Gi/o-coupled GPCRs are all known to regulate mitogenesis via the transactivation of Src-dependent integrin signalling complexes. Gq- and Gi/o-coupled receptors also utilize Src to activate a variety of MAPK pathways. Gs-, Gi/o- and Gq-coupled receptors promote proliferation via the activation of the STAT transcription factors, and this has been postulated to be Src-dependent (shown in dashed lines). Full STAT activity may require phosphorylation by JAKs and MAPKs. Dashed lines also identify the probable involvement of multiple, unidentified intermediates in the transcriptional regulation of cell cycle proteins.